Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts
文献类型：期刊论文
| 作者 | Li, QR; Wang, M; Tan, L; Wang, C; Ma, J; Li, N; Li, YS; Xu, GW; Li, JS |
| 刊名 | journal of lipid research
 |
| 出版日期 | 2005-09-01 |
| 卷号 | 46期号:9页码:1904-1913 |
| 关键词 | polyunsaturated fatty acids lipid rafts fatty acid composition Janus kinase-signal transducer and activator of transcription signaling pathway |
| 产权排序 | 2;4 |
| 通讯作者 | 许国旺 |
| 英文摘要 | polyunsaturated fatty acids, including docosahexaenoic acid (dha, 22:6n-3), modulate immune responses and exert beneficial immunosuppressive effects, but the molecular mechanisms inhibiting t-cell activation are not yet elucidated. lipid rafts have been shown to play an important role in the compartmentalization and modulation of cell signaling. we investigated the role of dha in modulating the lipid composition in lipid rafts and membrane subdomain distribution of interleukin-2 ( il-2) receptor signaling molecules. we found that dha altered lipid components of rafts and modified the il-2-induced janus kinase-signal transducer and activator of transcription (stat) signaling pathway by partially displacing il-2 receptors from lipid rafts. we fractionated plasma membrane subcellular compartments and discovered that certain amounts of stat5a and stat5b existed in detergent-resistant plasma membrane fractions of t-cells. after dha treatment, stat5a and stat5b were not detected in lipid raft fractions and were located in detergent-soluble fractions. these data demonstrate for the first time that dha alters the lipid composition of membrane microdomains and suppresses il-2 receptor signaling in t- cells. thus, our data provide evidence for a functional modification in lipid rafts by dha treatment and explain pufa- mediated immunosuppressive effects. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | polyunsaturated fatty-acids ; protein-tyrosine kinases ; dietary fish-oil ; rheumatoid-arthritis ; gpi-microdomains ; receptor ; activation ; pathway ; stats ; supplementation |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000231244200012 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/97481]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China 2.Chinese Acad Sci, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China 3.Chinese Acad Sci, Inst Chem Phys, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, QR,Wang, M,Tan, L,et al. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts[J]. journal of lipid research,2005,46(9):1904-1913. |
| APA | Li, QR.,Wang, M.,Tan, L.,Wang, C.,Ma, J.,...&Li, JS.(2005).Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts.journal of lipid research,46(9),1904-1913. |
| MLA | Li, QR,et al."Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts".journal of lipid research 46.9(2005):1904-1913. |
入库方式： OAI收割
来源：大连化学物理研究所
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