Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms
文献类型：期刊论文
| 作者 | Gu, JD ; Fan, YZ ; Shi, HC |
| 刊名 | MARINE POLLUTION BULLETIN
 |
| 出版日期 | 2002 |
| 卷号 | 45期号:40555页码:379-384 |
| 关键词 | anaerobic degradation indole metabolic pathway methanogenic condition substitution sulfate-reducing condition |
| ISSN号 | 0025-326X |
| 中文摘要 | Degradation of selected indolic compounds including indole, 1-methylindole, 2-methylindole, and 3-methylindole was assessed under methanogenic and sulfate-reducing conditions using the serum-bottle anaerobic technique and marine sediment from Victoria Harbour, Hong Kong as an inoculum. Our results showed that indole degradation was achieved in 28 days by a methanogenic consortium and 35 days by a sulfate-reducing consortium. During degradation under both conditions, two intermediates were isolated, purified and identified as oxindole and isatin (indole-2,3-dione) suggesting that both methanogenic and sulfate-reducing bacteria use an identical degradation pathway. Degradation processes followed two steps of oxidation accomplished by hydroxylation and then dehydrogenation at 2- and then 3-position sequentially prior to the cleavage of the pyrrole ring between 2- and 3-positions. However, none of 1-methylindole or 2-methylindole was degraded under any conditions. 3-Methylindole (3-methyl-1H-indole, skatole) was transformed under methanogenic conditions and mineralized only under sulfate-reducing conditions. It is clear that methyl substitution on 1- or 2-position inhibits the initial attack by hydroxylation enzymes making them more persistent in the environment and posing longer toxic impact. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| 学科主题 | Environmental Sciences; Marine & Freshwater Biology |
| 收录类别 | SCI |
| 原文出处 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000178336300049 |
| 公开日期 | 2011-07-03 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/4708]  |
| 专题 | 南海海洋研究所_中科院边缘海地质重点实验室 |
| 推荐引用方式 GB/T 7714 | Gu, JD,Fan, YZ,Shi, HC. Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms[J]. MARINE POLLUTION BULLETIN,2002,45(40555):379-384. |
| APA | Gu, JD,Fan, YZ,&Shi, HC.(2002).Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms.MARINE POLLUTION BULLETIN,45(40555),379-384. |
| MLA | Gu, JD,et al."Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms".MARINE POLLUTION BULLETIN 45.40555(2002):379-384. |
入库方式： OAI收割
来源：南海海洋研究所
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