Proteomics: addressing the challenges of multiple myeloma
文献类型：期刊论文
| 作者 | Ge, Feng1; Tao, Shengce2; Bi, Lijun3; Zhang, Zhiping4; Zhang, Xian'En4 |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2011-02-01 |
| 卷号 | 43期号:2页码:89-95 |
| 关键词 | proteomics multiple myeloma biomarkers mass spectrometry post-translational modifications |
| ISSN号 | 1672-9145 |
| 通讯作者 | Ge, F, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; gefeng@ihb.ac.cn, x.zhang@wh.iov.cn |
| 中文摘要 | Multiple myeloma (MM) is a malignancy of terminally differentiated B-lymphocytes that accounts for similar to 13% of all hematologic cancers. Despite a wealth of knowledge describing the molecular biology of MM as well as significant advances in therapeutics, this disease remains incurable. Since proteins govern the cellular structure and biological function, a wide selection of proteomic approaches holds great promise for increasing our understanding of this disease, such as by investigating the dynamic nature of protein expression, cellular and subcellular distribution, post-translational modifications, and interactions at both the cellular and subcellular levels. The aims of this review are to introduce the available and emerging proteomic technologies that have potential applications in the study of MM and to highlight the current status of proteomic studies of MM. To date, although there have been a limited number of proteomic studies in MM, those performed have provided valuable information with regard to MM diagnosis and therapy. The potential future application of proteomic technologies is expected to provide new avenues in MM diagnostics, individualized therapy design and therapy response surveillance for the clinician. |
| 英文摘要 | Multiple myeloma (MM) is a malignancy of terminally differentiated B-lymphocytes that accounts for similar to 13% of all hematologic cancers. Despite a wealth of knowledge describing the molecular biology of MM as well as significant advances in therapeutics, this disease remains incurable. Since proteins govern the cellular structure and biological function, a wide selection of proteomic approaches holds great promise for increasing our understanding of this disease, such as by investigating the dynamic nature of protein expression, cellular and subcellular distribution, post-translational modifications, and interactions at both the cellular and subcellular levels. The aims of this review are to introduce the available and emerging proteomic technologies that have potential applications in the study of MM and to highlight the current status of proteomic studies of MM. To date, although there have been a limited number of proteomic studies in MM, those performed have provided valuable information with regard to MM diagnosis and therapy. The potential future application of proteomic technologies is expected to provide new avenues in MM diagnostics, individualized therapy design and therapy response surveillance for the clinician. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | SPECTROMETRY-BASED PROTEOMICS ; PROTEIN IDENTIFICATION TECHNOLOGY ; MASS-SPECTROMETRY ; PLASMA-CELLS ; QUANTITATIVE PROTEOMICS ; LIQUID-CHROMATOGRAPHY ; GEL-ELECTROPHORESIS ; INDUCED APOPTOSIS ; KNOCKDOWN QUICK ; LC-MS |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Sciences ; National Protein Research Fund [2009CB825400, 2006CB910902]; Ministry of Health of China [2008ZX10003-005]; State Key Development Program for Basic Research of China [2010CB529205]; Program for New Century Excellent Talents in University [NCET-09-551] |
| 语种 | 英语 |
| WOS记录号 | WOS:000286670900001 |
| 公开日期 | 2011-04-14 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/15524]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China 2.Shanghai Jiao Tong Univ, Minist Educ, Key Lab Syst Biomed, Shanghai Ctr Syst Biomed, Shanghai 200240, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, Feng,Tao, Shengce,Bi, Lijun,et al. Proteomics: addressing the challenges of multiple myeloma[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2011,43(2):89-95. |
| APA | Ge, Feng,Tao, Shengce,Bi, Lijun,Zhang, Zhiping,&Zhang, Xian'En.(2011).Proteomics: addressing the challenges of multiple myeloma.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,43(2),89-95. |
| MLA | Ge, Feng,et al."Proteomics: addressing the challenges of multiple myeloma".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 43.2(2011):89-95. |
入库方式： OAI收割
来源：水生生物研究所
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