Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol
文献类型：期刊论文
| 作者 | Liu, Chunsheng1,2; Deng, Jun1; Yu, Liqin1; Ramesh, Mathan3; Zhou, Bingsheng1 |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2010-01-21 |
| 卷号 | 96期号:1页码:70-76 |
| 关键词 | Fluorotelomer alcohols Fecundity Gamatogenesis Sex hormone Gene transcription Reproductive toxicity |
| ISSN号 | 0166-445X |
| 通讯作者 | Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 中文摘要 | The fluorotelomer alcohols (FTOHs) have been detected in the aquatic environment and shown potential estrogenic activity, but the effects on fish reproduction remain unknown. In the present study, 4-month-old zebrafish were exposed to different concentrations of 8:2 FTOH (0, 10, 30, 90, 270 mu g/L) for 4 weeks, and the impact on reproduction was investigated. The plasma testosterone (T) and estradiol (E2) levels were significantly increased in the females, while T and E2 levels were decreased and increased in the males, respectively. The average number of eggs spawned and sperm production were reduced upon exposure to the chemical,which also resulted in thinning of eggshell, and reduced protein content and egg diameter. Histological examination showed promotion of oocyte maturation and retarded spermiation in female and male fish, respectively. The gene transcription of follicle-stimulating hormone beta (FSH beta) and luteinizing hormone beta (LH beta) in the pituitary were up- and down-regulated in female and male fish, respectively. Up-regulation of vitellogenin (VTG1) and zona pellucida protein 2 (ZP2a) gene transcription was observed in the males, indicating estrogenic activity. However, down-regulation of gene transcription of VTG1 and ZP2a was measured in the females, associated with decreased fecundity. In addition, exposure of adult zebrafish to 8:2 FTOH caused reduced hatching rates in the offspring. The results demonstrated that waterborne exposure to 8:2 FTOH caused disruption of sex hormone biosynthesis and impaired reproduction in adult zebrafish, ultimately resulting in decreased hatching rates in the offspring. (C) 2009 Elsevier B.V. All rights reserved. |
| 英文摘要 | The fluorotelomer alcohols (FTOHs) have been detected in the aquatic environment and shown potential estrogenic activity, but the effects on fish reproduction remain unknown. In the present study, 4-month-old zebrafish were exposed to different concentrations of 8:2 FTOH (0, 10, 30, 90, 270 mu g/L) for 4 weeks, and the impact on reproduction was investigated. The plasma testosterone (T) and estradiol (E2) levels were significantly increased in the females, while T and E2 levels were decreased and increased in the males, respectively. The average number of eggs spawned and sperm production were reduced upon exposure to the chemical,which also resulted in thinning of eggshell, and reduced protein content and egg diameter. Histological examination showed promotion of oocyte maturation and retarded spermiation in female and male fish, respectively. The gene transcription of follicle-stimulating hormone beta (FSH beta) and luteinizing hormone beta (LH beta) in the pituitary were up- and down-regulated in female and male fish, respectively. Up-regulation of vitellogenin (VTG1) and zona pellucida protein 2 (ZP2a) gene transcription was observed in the males, indicating estrogenic activity. However, down-regulation of gene transcription of VTG1 and ZP2a was measured in the females, associated with decreased fecundity. In addition, exposure of adult zebrafish to 8:2 FTOH caused reduced hatching rates in the offspring. The results demonstrated that waterborne exposure to 8:2 FTOH caused disruption of sex hormone biosynthesis and impaired reproduction in adult zebrafish, ultimately resulting in decreased hatching rates in the offspring. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Marine & Freshwater Biology; Toxicology |
| 类目[WOS] | Marine & Freshwater Biology ; Toxicology |
| 研究领域[WOS] | Marine & Freshwater Biology ; Toxicology |
| 关键词[WOS] | MINNOW PIMEPHALES-PROMELAS ; MEDAKA ORYZIAS-LATIPES ; DANIO-RERIO ; PERFLUORINATED CHEMICALS ; OOCYTE MATURATION ; GAMETE QUALITY ; ESTROGEN ; VITELLOGENIN ; GONADOTROPIN ; EXPRESSION |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] |
| 语种 | 英语 |
| WOS记录号 | WOS:000274758200007 |
| 公开日期 | 2010-12-23 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/13721]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Bharathiar Univ, Dept Zool, Toxicol Unit, Coimbatore 641046, Tamil Nadu, India |
| 推荐引用方式 GB/T 7714 | Liu, Chunsheng,Deng, Jun,Yu, Liqin,et al. Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol[J]. AQUATIC TOXICOLOGY,2010,96(1):70-76. |
| APA | Liu, Chunsheng,Deng, Jun,Yu, Liqin,Ramesh, Mathan,&Zhou, Bingsheng.(2010).Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol.AQUATIC TOXICOLOGY,96(1),70-76. |
| MLA | Liu, Chunsheng,et al."Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol".AQUATIC TOXICOLOGY 96.1(2010):70-76. |
入库方式： OAI收割
来源：水生生物研究所
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