Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction
文献类型：期刊论文
| 作者 | Deng, Jun1,2; Liu, Chunsheng1; Yu, Liqin1; Zhou, Bingsheng1 |
| 刊名 | TOXICOLOGY AND APPLIED PHARMACOLOGY
 |
| 出版日期 | 2010-02-15 |
| 卷号 | 243期号:1页码:87-95 |
| 关键词 | Tribromophenol Endocrine disruption Sex hormones Steroidogenic genes Reproduction Zebrafish |
| ISSN号 | 0041-008X |
| 通讯作者 | Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 中文摘要 | Tribromophenol (2,4,6-TBP) is ubiquitously found in aquatic environments and biota. In this study, we exposed zebrafish embryos (F-0; 2 '''' days post-fertilization, dpf) to environmental concentration (0.3 mu g/L) and a higher concentration (3.0 mu g/L) of TBP and assessed the impact of chronic exposure (120 dpf) on reproduction. TBP exposure did not cause a significant increase in the malformation and reduction in the survival in the F-0-generation fish. After TBP exposure, the plasma testosterone and estradiol levels significantly increased in males and decreased in females. The transcription of steroidogenic genes (3 beta-HSD, 17 beta-HSD, CYP17, CYP19A, CYP19B) was significantly upregulated in the brain and testes in males and downregulated in the brain and ovary in females. TBP exposure significantly downregulated and upregulated the expression of VTG in the liver of female and male fish, respectively. Meanwhile, TBP exposure altered the sex ratio toward a male-dominant state. The F-1-generation larvae exhibited increased malformation, reduced survival, and retarded growth, suggesting that TBP in the aquatic environment has significant adverse effects on fish population. (C) 2009 Elsevier Inc. All rights reserved |
| 英文摘要 | Tribromophenol (2,4,6-TBP) is ubiquitously found in aquatic environments and biota. In this study, we exposed zebrafish embryos (F(0); 2 '''' days post-fertilization, dpf) to environmental concentration (0.3 mu g/L) and a higher concentration (3.0 mu g/L) of TBP and assessed the impact of chronic exposure (120 dpf) on reproduction. TBP exposure did not cause a significant increase in the malformation and reduction in the survival in the F(0)-generation fish. After TBP exposure, the plasma testosterone and estradiol levels significantly increased in males and decreased in females. The transcription of steroidogenic genes (3 beta-HSD, 17 beta-HSD, CYP17, CYP19A, CYP19B) was significantly upregulated in the brain and testes in males and downregulated in the brain and ovary in females. TBP exposure significantly downregulated and upregulated the expression of VTG in the liver of female and male fish, respectively. Meanwhile, TBP exposure altered the sex ratio toward a male-dominant state. The F(1)-generation larvae exhibited increased malformation, reduced survival, and retarded growth, suggesting that TBP in the aquatic environment has significant adverse effects on fish population. (C) 2009 Elsevier Inc. All rights reserved |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | BROMINATED FLAME RETARDANTS ; MINNOW PIMEPHALES-PROMELAS ; MEDAKA ORYZIAS-LATIPES ; LIFE-CYCLE TEST ; DANIO-RERIO ; DEVELOPMENTAL EXPOSURE ; AROMATASE INHIBITOR ; GAS-CHROMATOGRAPHY ; SYNTHETIC ESTROGEN ; GOBIOCYPRIS-RARUS |
| 收录类别 | SCI |
| 资助信息 | Ministry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] |
| 语种 | 英语 |
| WOS记录号 | WOS:000274489700011 |
| 公开日期 | 2010-12-23 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/13723]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Jun,Liu, Chunsheng,Yu, Liqin,et al. Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2010,243(1):87-95. |
| APA | Deng, Jun,Liu, Chunsheng,Yu, Liqin,&Zhou, Bingsheng.(2010).Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction.TOXICOLOGY AND APPLIED PHARMACOLOGY,243(1),87-95. |
| MLA | Deng, Jun,et al."Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction".TOXICOLOGY AND APPLIED PHARMACOLOGY 243.1(2010):87-95. |
入库方式： OAI收割
来源：水生生物研究所
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