High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis
文献类型：期刊论文
| 作者 | Du, Hejun1,2; Zheng, Jinsong1; Wu, Min1,2; Zhao, Qingzhong1; Wang, Ding1 |
| 刊名 | BIOCHEMICAL GENETICS
 |
| 出版日期 | 2010-06-01 |
| 卷号 | 48期号:5-6页码:433-449 |
| 关键词 | Yangtze finless porpoise DQB Genetic variation Balancing selection Conservation |
| ISSN号 | 0006-2928 |
| 通讯作者 | Zheng, JS, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China |
| 中文摘要 | The endangered Yangtze finless porpoise is found in the middle and lower reaches of the Yangtze River and its adjoining big lakes. To explore the major histocompatibility complex (MHC) genetic diversity and allelic distribution patterns across its range, we investigated variation at DQB exon 2. From 76 porpoises, we identified 18 DQB sequences. The freshwater Yangtze populations had much higher allelic diversity than marine populations. Among these freshwater populations, the middle-reach population had higher allelic diversity than the lower-reach population. The high DQB diversity level, relative to that of a neutral mtDNA locus, suggests that balancing selection is acting at the DQB gene and that rapid evolution and local positive selection play critical roles in generating and retaining high MHC diversity in the freshwater population. As the balancing selection might be driven by environmental pathogens, we suggest that maintaining MHC variation should be a high priority in the conservation and management of this endangered population, especially as an ex situ conservation strategy. |
| 英文摘要 | The endangered Yangtze finless porpoise is found in the middle and lower reaches of the Yangtze River and its adjoining big lakes. To explore the major histocompatibility complex (MHC) genetic diversity and allelic distribution patterns across its range, we investigated variation at DQB exon 2. From 76 porpoises, we identified 18 DQB sequences. The freshwater Yangtze populations had much higher allelic diversity than marine populations. Among these freshwater populations, the middle-reach population had higher allelic diversity than the lower-reach population. The high DQB diversity level, relative to that of a neutral mtDNA locus, suggests that balancing selection is acting at the DQB gene and that rapid evolution and local positive selection play critical roles in generating and retaining high MHC diversity in the freshwater population. As the balancing selection might be driven by environmental pathogens, we suggest that maintaining MHC variation should be a high priority in the conservation and management of this endangered population, especially as an ex situ conservation strategy. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Biochemistry & Molecular Biology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 关键词[WOS] | MAJOR HISTOCOMPATIBILITY COMPLEX ; POPULATION GENETIC-STRUCTURE ; CLASS-II LOCI ; BALANCING SELECTION ; SEQUENCE VARIATION ; NUCLEOTIDE SUBSTITUTION ; OVERDOMINANT SELECTION ; DELPHINAPTERUS-LEUCAS ; MICROSATELLITE LOCI ; RIVER DOLPHIN |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252] |
| 语种 | 英语 |
| WOS记录号 | WOS:000277425600007 |
| 公开日期 | 2010-12-23 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/13481]  |
| 专题 | 水生生物研究所_水生生物多样性与资源保护研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Hejun,Zheng, Jinsong,Wu, Min,et al. High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis[J]. BIOCHEMICAL GENETICS,2010,48(5-6):433-449. |
| APA | Du, Hejun,Zheng, Jinsong,Wu, Min,Zhao, Qingzhong,&Wang, Ding.(2010).High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis.BIOCHEMICAL GENETICS,48(5-6),433-449. |
| MLA | Du, Hejun,et al."High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis".BIOCHEMICAL GENETICS 48.5-6(2010):433-449. |
入库方式： OAI收割
来源：水生生物研究所
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