Olfactory receptor gene family evolution in stickleback and medaka fishes
文献类型：期刊论文
| 作者 | Chen Ming1,2; Peng ZuoGang1; He ShunPing1 |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2010-02-01 |
| 卷号 | 53期号:2页码:257-266 |
| 关键词 | olfactory receptor positive selection binding site |
| ISSN号 | 1674-7305 |
| 通讯作者 | He, SP, Chinese Acad Sci, Lab Fish Phylogenet & Biogeog, Inst Hydrobiol, Wuhan 430072, Peoples R China |
| 中文摘要 | Interaction of olfactory receptor (OR) genes with environmental odors is regarded as the first step of olfaction. In this study, OR genes of two fish, medaka (Oryzias latipes) and stickleback (Gasterosteus aculeatus), were identified and an evolutional analysis was conducted. The selection pressure of different TM regions and complete coding region were compared. Three TM regions (TM4, TM5 and TM6) were found to have higher average Ka/Ks values, which might be partly caused by positive selection as suggested by subsequent positive selection analysis. Further analysis showed that many PTSs overlap, or are adjacent to previously deduced binding sites in mammals. These results support the hypothesis that binding sites of fish OR genes may evolved under positive selection. |
| 英文摘要 | Interaction of olfactory receptor (OR) genes with environmental odors is regarded as the first step of olfaction. In this study, OR genes of two fish, medaka (Oryzias latipes) and stickleback (Gasterosteus aculeatus), were identified and an evolutional analysis was conducted. The selection pressure of different TM regions and complete coding region were compared. Three TM regions (TM4, TM5 and TM6) were found to have higher average Ka/Ks values, which might be partly caused by positive selection as suggested by subsequent positive selection analysis. Further analysis showed that many PTSs overlap, or are adjacent to previously deduced binding sites in mammals. These results support the hypothesis that binding sites of fish OR genes may evolved under positive selection. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Biology |
| 类目[WOS] | Biology |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics |
| 关键词[WOS] | CODON-SUBSTITUTION MODELS ; PROTEIN-COUPLED RECEPTORS ; ODORANT-BINDING-SITE ; SEQUENCE ALIGNMENT ; NUCLEOTIDE SUBSTITUTION ; OVERDOMINANT SELECTION ; PHYLOGENETIC ANALYSIS ; MAXIMUM-LIKELIHOOD ; MOLECULAR-BASIS ; MOUSE |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [30600062, 30530120] |
| 语种 | 英语 |
| WOS记录号 | WOS:000276438100016 |
| 公开日期 | 2010-12-23 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/13489]  |
| 专题 | 水生生物研究所_水生生物多样性与资源保护研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Lab Fish Phylogenet & Biogeog, Inst Hydrobiol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen Ming,Peng ZuoGang,He ShunPing. Olfactory receptor gene family evolution in stickleback and medaka fishes[J]. SCIENCE CHINA-LIFE SCIENCES,2010,53(2):257-266. |
| APA | Chen Ming,Peng ZuoGang,&He ShunPing.(2010).Olfactory receptor gene family evolution in stickleback and medaka fishes.SCIENCE CHINA-LIFE SCIENCES,53(2),257-266. |
| MLA | Chen Ming,et al."Olfactory receptor gene family evolution in stickleback and medaka fishes".SCIENCE CHINA-LIFE SCIENCES 53.2(2010):257-266. |
入库方式： OAI收割
来源：水生生物研究所
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