Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats
文献类型：期刊论文
| 作者 | Hao, Le1,2; Xie, Ping1; Ha, Huiying1; Li, Guangyu1,2; Xiong, Qian1,2; Wang, Qing1; Qiu, Tong1; Liu, Ying1 |
| 刊名 | TOXICON
 |
| 出版日期 | 2010-06-15 |
| 卷号 | 55期号:7页码:1378-1386 |
| 关键词 | Microcystin Cytoskeletal Hepatotoxicity Tumor-promotion Neurotoxicity |
| ISSN号 | 0041-0101 |
| 通讯作者 | Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu S Rd 7, Wuhan 430072, Peoples R China |
| 中文摘要 | This study explored the mechanisms of toxicity of microcystins by measuring the transcription levels of nine cytoskeletal genes (actin, tubulin, vimentin, ezrin, radixin, moesin, MAP1b, tau, stathmin) in the liver, kidney and spleen of male Wistar rats treated with microcystins at a dose of 80 mu g MC-LReq kg(-1) bw. Microcystins disrupted the transcriptional homeostasis of cytoskeletal genes in these organs. Changes in the transcription of four genes (beta-actin, ezrin, radixin and tau) in liver, one gene (stathmin) in kidney, and one gene (radixin) in spleen were significantly correlated with the tissue concentration of microcystins. However, the influences on the transcription of most genes we studied were greater in the liver than in the kidney or spleen. The effects of microcystins on the transcription of cytoskeletal genes may explain some of the morphological and pathological changes observed in these organs and provide new information on the hepatotoxicity of these compounds. Additionally, transcriptional changes in tumor-associated cytoskeletal genes (ezrin, moesin and stathmin) that were observed in the present study provide a possible clue to the tumor-promoting potential of microcystins and their influences on the transcription of MAP1b and tau imply possible neurological toxicity of microcystins in vertebrates. (C) 2010 Published by Elsevier Ltd. |
| 英文摘要 | This study explored the mechanisms of toxicity of microcystins by measuring the transcription levels of nine cytoskeletal genes (actin, tubulin, vimentin, ezrin, radixin, moesin, MAP1b, tau, stathmin) in the liver, kidney and spleen of male Wistar rats treated with microcystins at a dose of 80 mu g MC-LReq kg(-1) bw. Microcystins disrupted the transcriptional homeostasis of cytoskeletal genes in these organs. Changes in the transcription of four genes (beta-actin, ezrin, radixin and tau) in liver, one gene (stathmin) in kidney, and one gene (radixin) in spleen were significantly correlated with the tissue concentration of microcystins. However, the influences on the transcription of most genes we studied were greater in the liver than in the kidney or spleen. The effects of microcystins on the transcription of cytoskeletal genes may explain some of the morphological and pathological changes observed in these organs and provide new information on the hepatotoxicity of these compounds. Additionally, transcriptional changes in tumor-associated cytoskeletal genes (ezrin, moesin and stathmin) that were observed in the present study provide a possible clue to the tumor-promoting potential of microcystins and their influences on the transcription of MAP1b and tau imply possible neurological toxicity of microcystins in vertebrates. (C) 2010 Published by Elsevier Ltd. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | PHYTOPLANKTIVOROUS BIGHEAD CARP ; MICROTUBULE-ASSOCIATED PROTEINS ; KERATIN INTERMEDIATE-FILAMENTS ; ABNORMALLY PHOSPHORYLATED-TAU ; PAIRED HELICAL FILAMENTS ; ALZHEIMER-DISEASE BRAIN ; CYCLIC PEPTIDE TOXIN ; BLUE-GREEN-ALGA ; NEUROFIBRILLARY DEGENERATION ; HEPATOTOXIC MICROCYSTINS |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] |
| 语种 | 英语 |
| WOS记录号 | WOS:000277881900021 |
| 公开日期 | 2010-12-23 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/13536]  |
| 专题 | 水生生物研究所_淡水生态学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Sch, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Le,Xie, Ping,Ha, Huiying,et al. Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats[J]. TOXICON,2010,55(7):1378-1386. |
| APA | Hao, Le.,Xie, Ping.,Ha, Huiying.,Li, Guangyu.,Xiong, Qian.,...&Liu, Ying.(2010).Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats.TOXICON,55(7),1378-1386. |
| MLA | Hao, Le,et al."Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats".TOXICON 55.7(2010):1378-1386. |
入库方式： OAI收割
来源：水生生物研究所
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