Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS
文献类型：期刊论文
| 作者 | Liang, Gaodao1,2; Xie, Ping1; Chen, Jun1; Yu, Ting1 |
| 刊名 | THESCIENTIFICWORLDJOURNAL
 |
| 出版日期 | 2011 |
| 卷号 | 11页码:20-26 |
| 关键词 | mcrocystins n-octanol/water distribution ratio pH |
| ISSN号 | 1537-744X |
| 通讯作者 | Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan, Peoples R China ; xieping@ihb.ac.cn, chenjun@ihb.ac.cn |
| 中文摘要 | Microcystins (MCs) are well known worldwide as hepatotoxins produced by cyanobacteria, but little is known about the physicochemical properties of these compounds. The dependence of the n-octanol/water distribution ratio (DOW) of MC-RR and -LR to pH was measured by high-performance liquid chromatography combined with mass spectrometry (LC-MS). There was a remarkable difference in such relationships between MC-RR and -LR. The log DOW of MC-LR decreased from 1.63 at pH 1.0 to -1.26 at pH 6.5, and stabilized between -1.04 and -1.56 at a pH of 6.5 similar to 12.0; log DOW of MC-RR varied between -1.24 and -0.67 at a pH of 1.00 similar to 4.00, and stabilized between -1.20 and -1.54 at a pH of 4.00 similar to 12.00. The difference of hydrophobicity in acidic condition between MC-RR and -LR is important, not only for the analytical method of both toxins, but perhaps also for understanding the difference of toxicity to animals between the two toxins. |
| 英文摘要 | Microcystins (MCs) are well known worldwide as hepatotoxins produced by cyanobacteria, but little is known about the physicochemical properties of these compounds. The dependence of the n-octanol/water distribution ratio (DOW) of MC-RR and -LR to pH was measured by high-performance liquid chromatography combined with mass spectrometry (LC-MS). There was a remarkable difference in such relationships between MC-RR and -LR. The log DOW of MC-LR decreased from 1.63 at pH 1.0 to -1.26 at pH 6.5, and stabilized between -1.04 and -1.56 at a pH of 6.5 similar to 12.0; log DOW of MC-RR varied between -1.24 and -0.67 at a pH of 1.00 similar to 4.00, and stabilized between -1.20 and -1.54 at a pH of 4.00 similar to 12.00. The difference of hydrophobicity in acidic condition between MC-RR and -LR is important, not only for the analytical method of both toxins, but perhaps also for understanding the difference of toxicity to animals between the two toxins. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Environmental Sciences; Multidisciplinary Sciences |
| 类目[WOS] | Environmental Sciences ; Multidisciplinary Sciences |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Science & Technology - Other Topics |
| 关键词[WOS] | CYANOBACTERIAL TOXINS ; LIQUID-CHROMATOGRAPHY ; WATER ; ACCUMULATION ; CHINA ; LIVER |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101] |
| 语种 | 英语 |
| WOS记录号 | WOS:000286474700002 |
| 公开日期 | 2011-04-14 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/15474]  |
| 专题 | 水生生物研究所_淡水生态学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan, Peoples R China 2.Wuhan Ctr Dis Prevent & Control, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Gaodao,Xie, Ping,Chen, Jun,et al. Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS[J]. THESCIENTIFICWORLDJOURNAL,2011,11:20-26. |
| APA | Liang, Gaodao,Xie, Ping,Chen, Jun,&Yu, Ting.(2011).Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS.THESCIENTIFICWORLDJOURNAL,11,20-26. |
| MLA | Liang, Gaodao,et al."Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS".THESCIENTIFICWORLDJOURNAL 11(2011):20-26. |
入库方式： OAI收割
来源：水生生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。