Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis
文献类型：期刊论文
| 作者 | Li, Guang-Yu; Xie, Ping; Li, Hui-Ying; Hao, Le; Xiong, Qian; Qiu, Tong |
| 刊名 | ENVIRONMENTAL TOXICOLOGY
 |
| 出版日期 | 2011-04-01 |
| 卷号 | 26期号:2页码:111-117 |
| 关键词 | microcystin apoptosis real time PCR Wistar rat Bcl-2 Bax P53 |
| ISSN号 | 1520-4081 |
| 通讯作者 | Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu South Rd 7, Wuhan 430072, Peoples R China ; xieping@ihb.ac.cn |
| 中文摘要 | It has been reported that microcystins (MCs) could accumulate in the gonads of mammals and MCs exposure exerts obvious toxic effects on male reproductive system of mammals. We have comfirmed that MCs could accumulate and induce apoptosis in rat testis. The p53, Bax, and Bcl-2 protein play important roles in mitochondria-dependent apoptotic pathway, and this study aimed to investigate whether the p53, Bax, and Bcl-2 pathway is involved in microcystins-induced apoptosis in rat testis and discussed the possible mechanisms. Our results show that MCs led to persistent increase of transcriptional and protein level of P53 and Bax expression but led to decrease of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which might contribute to apoptotic cell death of rat testis following MCs treatment. The increased ratio of expression of Bax to that of Bcl-2 induced by MCs suggests their important role in MCs-induced apoptosis in rat testis tissue. (c) 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 111-117, 2011. |
| 英文摘要 | It has been reported that microcystins (MCs) could accumulate in the gonads of mammals and MCs exposure exerts obvious toxic effects on male reproductive system of mammals. We have comfirmed that MCs could accumulate and induce apoptosis in rat testis. The p53, Bax, and Bcl-2 protein play important roles in mitochondria-dependent apoptotic pathway, and this study aimed to investigate whether the p53, Bax, and Bcl-2 pathway is involved in microcystins-induced apoptosis in rat testis and discussed the possible mechanisms. Our results show that MCs led to persistent increase of transcriptional and protein level of P53 and Bax expression but led to decrease of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which might contribute to apoptotic cell death of rat testis following MCs treatment. The increased ratio of expression of Bax to that of Bcl-2 induced by MCs suggests their important role in MCs-induced apoptosis in rat testis tissue. (c) 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 111-117, 2011. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 学科主题 | Environmental Sciences; Toxicology; Water Resources |
| 类目[WOS] | Environmental Sciences ; Toxicology ; Water Resources |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Toxicology ; Water Resources |
| 关键词[WOS] | TUMOR-SUPPRESSOR P53 ; GERM-CELL APOPTOSIS ; IN-VIVO ; FAMILY-MEMBERS ; P53-DEPENDENT APOPTOSIS ; TISSUE DISTRIBUTIONS ; PROTEIN PHOSPHATASE ; REPRODUCTIVE-SYSTEM ; SEASONAL DYNAMICS ; SUBTROPICAL CHINA |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China (973 Program) [2008CB418101] |
| 语种 | 英语 |
| WOS记录号 | WOS:000288652000001 |
| 公开日期 | 2011-06-30 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/15602]  |
| 专题 | 水生生物研究所_淡水生态学研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Guang-Yu,Xie, Ping,Li, Hui-Ying,et al. Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis[J]. ENVIRONMENTAL TOXICOLOGY,2011,26(2):111-117. |
| APA | Li, Guang-Yu,Xie, Ping,Li, Hui-Ying,Hao, Le,Xiong, Qian,&Qiu, Tong.(2011).Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis.ENVIRONMENTAL TOXICOLOGY,26(2),111-117. |
| MLA | Li, Guang-Yu,et al."Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis".ENVIRONMENTAL TOXICOLOGY 26.2(2011):111-117. |
入库方式： OAI收割
来源：水生生物研究所
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