Mtmr8 is essential for vasculature development in zebrafish embryos
文献类型：期刊论文
| 作者 | Mei, Jie; Liu, Sha; Li, Zhi; Gui, Jian-Fang |
| 刊名 | BMC DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2010-09-05 |
| 卷号 | 10页码:- |
| 关键词 | ENDOTHELIAL-GROWTH-FACTOR PROTEIN-KINASE-A GENE-EXPRESSION SONIC-HEDGEHOG CELL SURVIVAL ANGIOGENESIS DIFFERENTIATION VASCULOGENESIS PATHWAY MUSCLE |
| ISSN号 | 1471-213X |
| 通讯作者 | Gui, JF, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Ctr Dev Biol, Inst Hydrobiol,Grad Sch, Wuhan 430072, Peoples R China |
| 中文摘要 | Background: Embryonic morphogenesis of vascular and muscular systems is tightly coordinated, and a functional cooperation of Mtmr8 with PI3K in actin filament modeling and muscle development has been revealed in zebrafish. Here, we attempt to explore the function of Mtmr8 in vasculature development parallel to its function in muscle development. Results: During early stage of somitogenesis, mtmr8 expression was detected in both somitic mesodem and ventral mesoderm. Knockdown of mtmr8 by morpholino impairs arterial endothelial marker expression, and results in endothelial cell reduction and vasculogenesis defects, such as retardation in intersegmental vessel development and interruption of trunk dorsal aorta. Moreover, mtmr8 morphants show loss of arterial endothelial cell identity in dorsal aorta, which is effectively rescued by low concentration of PI3K inhibitor, and by over-expression of dnPKA mRNA or vegf mRNA. Interestingly, mtmr8 expression is up-regulated when zebrafish embryos are treated with specific inhibitor of Hedgehog pathway that abolishes arterial marker expression. Conclusion: These data indicate that Mtmr8 is essential for vasculature development in zebrafish embryos, and may play a role in arterial specification through repressing PI3K activity. It is suggested that Mtmr8 should represent a novel element of the Hedgehog/PI3K/VEGF signaling cascade that controls arterial specification. |
| 英文摘要 | Background: Embryonic morphogenesis of vascular and muscular systems is tightly coordinated, and a functional cooperation of Mtmr8 with PI3K in actin filament modeling and muscle development has been revealed in zebrafish. Here, we attempt to explore the function of Mtmr8 in vasculature development parallel to its function in muscle development. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 研究领域[WOS] | Developmental Biology |
| 关键词[WOS] | ENDOTHELIAL-GROWTH-FACTOR ; PROTEIN-KINASE-A ; GENE-EXPRESSION ; SONIC-HEDGEHOG ; CELL SURVIVAL ; ANGIOGENESIS ; DIFFERENTIATION ; VASCULOGENESIS ; PATHWAY ; MUSCLE |
| 收录类别 | SCI |
| 资助信息 | National Major Basic Research Program [2010CB126300]; Chinese Academy of Sciences [KSCX2-YW-N-020, 075A01-1-301, 085A02-1-301]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ15]; IHB |
| 语种 | 英语 |
| WOS记录号 | WOS:000282741500001 |
| 公开日期 | 2010-12-23 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/13577]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Ctr Dev Biol, Inst Hydrobiol,Grad Sch, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mei, Jie,Liu, Sha,Li, Zhi,et al. Mtmr8 is essential for vasculature development in zebrafish embryos[J]. BMC DEVELOPMENTAL BIOLOGY,2010,10:-. |
| APA | Mei, Jie,Liu, Sha,Li, Zhi,&Gui, Jian-Fang.(2010).Mtmr8 is essential for vasculature development in zebrafish embryos.BMC DEVELOPMENTAL BIOLOGY,10,-. |
| MLA | Mei, Jie,et al."Mtmr8 is essential for vasculature development in zebrafish embryos".BMC DEVELOPMENTAL BIOLOGY 10(2010):-. |
入库方式： OAI收割
来源：水生生物研究所
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