Integration mechanisms of transgenes and population fitness of GH transgenic fish
文献类型：期刊论文
| 作者 | Hu Wei; Zhu ZuoYan |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 53期号:4页码:401-408 |
| 关键词 | transgene integration mechanism GH transgenic fish population fitness |
| ISSN号 | 1674-7305 |
| 通讯作者 | Zhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 中文摘要 | It has been more than 20 years since the first batch of transgenic fish was produced. Five stable germ-line transmitted growth hormone (GH) transgenic fish lines have been generated. This paper reviews the mechanisms of integration and gene targeting of the transgene, as well as the viability, reproduction and transgenic approaches for the reproductive containment of GH-transgenic fish. Further, we propose that it should be necessary to do the following studies, in particularly, of the breeding of transgenic fish: to assess the fitness of transgenic fish in an aqueous environment with a large space and a complex structure; and to develop a controllable on-off strategy of reproduction in transgenic fish. |
| 英文摘要 | It has been more than 20 years since the first batch of transgenic fish was produced. Five stable germ-line transmitted growth hormone (GH) transgenic fish lines have been generated. This paper reviews the mechanisms of integration and gene targeting of the transgene, as well as the viability, reproduction and transgenic approaches for the reproductive containment of GH-transgenic fish. Further, we propose that it should be necessary to do the following studies, in particularly, of the breeding of transgenic fish: to assess the fitness of transgenic fish in an aqueous environment with a large space and a complex structure; and to develop a controllable on-off strategy of reproduction in transgenic fish. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Biology |
| 类目[WOS] | Biology |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics |
| 关键词[WOS] | CARP CYPRINUS-CARPIO ; GROWTH-HORMONE GENE ; GONADOTROPIN-RELEASING-HORMONE ; SALMON ONCORHYNCHUS-KISUTCH ; ZINC-FINGER NUCLEASES ; COHO SALMON ; RAINBOW-TROUT ; ATLANTIC SALMON ; GERM-LINE ; SWIMMING PERFORMANCE |
| 收录类别 | SCI |
| 资助信息 | Development Plan of the State Key Fundamental Research of China [2007CB109205, 2007CB109206]; National Natural Science Foundation of China [30930069] |
| 语种 | 英语 |
| WOS记录号 | WOS:000277417800002 |
| 公开日期 | 2010-12-23 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/13621]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu Wei,Zhu ZuoYan. Integration mechanisms of transgenes and population fitness of GH transgenic fish[J]. SCIENCE CHINA-LIFE SCIENCES,2010,53(4):401-408. |
| APA | Hu Wei,&Zhu ZuoYan.(2010).Integration mechanisms of transgenes and population fitness of GH transgenic fish.SCIENCE CHINA-LIFE SCIENCES,53(4),401-408. |
| MLA | Hu Wei,et al."Integration mechanisms of transgenes and population fitness of GH transgenic fish".SCIENCE CHINA-LIFE SCIENCES 53.4(2010):401-408. |
入库方式： OAI收割
来源：水生生物研究所
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