Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals
文献类型：期刊论文
| 作者 | Lin, ZF ; Du, JW ; Yin, KD ; Wang, LS ; Yu, HX |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2004 |
| 卷号 | 54期号:11页码:1691-1701 |
| 关键词 | mechanism of concentration addition toxicity nonpolar narcotic chemical polar narcotic chemical reactive chemical |
| ISSN号 | 0045-6535 |
| 通讯作者 | lzhifen@yahoo.com |
| 中文摘要 | According to the toxicity mechanism of the individual chemicals, the concentration addition toxicity mechanism is revealed for nonpolar-narcotic-chemical mixtures, polar-narcotic-chemical mixtures and reactive-chemical mixtures, respectively. For nonpolar-narcotic-chemical mixtures, the partitioning of individual chemicals from water to biophase was determined, and the result shows that their concentration additive effect results from no competitive partitioning among individual chemicals. For polar-narcotic-chemical mixtures, their toxicity are contributed by two factors (the total baseline toxicity and the hydrogen bond donor activity of individual chemicals), and it is the concentration additive effect for either of these two factors that leads to their concentration addition toxicity. In addition, the interactions between the reactive chemicals and the biological macromolecules are discussed thoroughly. The results suggest that the net effect of these interactions is zero, and it is this zero net effect that leads to the concentration addition toxicity mechanism for reactive-chemical mixtures. (C) 2003 Elsevier Ltd. All rights reserved. |
| 学科主题 | Environmental Sciences |
| 收录类别 | SCI |
| 原文出处 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000189132000011 |
| 公开日期 | 2011-07-03 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/5663]  |
| 专题 | 南海海洋研究所_热带海洋环境国家重点实验室(LTO) |
| 推荐引用方式 GB/T 7714 | Lin, ZF,Du, JW,Yin, KD,et al. Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals[J]. CHEMOSPHERE,2004,54(11):1691-1701. |
| APA | Lin, ZF,Du, JW,Yin, KD,Wang, LS,&Yu, HX.(2004).Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals.CHEMOSPHERE,54(11),1691-1701. |
| MLA | Lin, ZF,et al."Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals".CHEMOSPHERE 54.11(2004):1691-1701. |
入库方式： OAI收割
来源：南海海洋研究所
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