Peptide self-assembly nanoparticles loaded with panobinostat to activate latent human immunodeficiency virus
文献类型:期刊论文
作者 | Kuai, Qiyuan1; Wang, Yu1; Gao, Fenghua1; Qi, Yingqiu2,3; Wang, Rui4; Wang, Yanbing1,5; Lu, Xiaofan4; Zhao, Ying2,6; Nie, Guangjun2,6; He, Min1 |
刊名 | Journal of biomedical nanotechnology |
出版日期 | 2019-05-01 |
卷号 | 15期号:5页码:979-992 |
ISSN号 | 1550-7033 |
关键词 | Hiv reservoir Latent hiv Histone deacetylase inhibitors Panobinostat Peptide self-assembly Nanoparticles |
DOI | 10.1166/jbn.2019.2764 |
通讯作者 | Jiang, xingwei(13910216274@163.com) ; Ren, suping(rensp12@yahoo.com) ; Yu, qun(yuqun1970@outlook.com) |
英文摘要 | Highly active antiretroviral therapy (haart) can turn human immunodeficiency virus-1 (hiv-1) infection into a controllable chronic disease, but because of the presence of an hiv reservoir, it cannot completely eliminate the virus in hiv-infected patients. the activation of latent reservoirs is the key to the successful treatment of acquired immune deficiency syndrome (aids). as a class of latency-reversing agents (lras), histone deacetylase inhibitors (hdacis), such as panobinostat, have been the most widely investigated, but most of them have resulted in only a modest and transient activation of hiv latency. to improve the potency of latency activation, an injectable peptide self-assembly nanoparticle loaded with panobinostat (pnp-p) was designed with the ability to efficiently penetrate the cell to achieve better drug delivery and activation of latent hiv. the results confirmed that these nanoparticles could activate latently infected cells in vitro and in vivo and activate peripheral blood mononuclear cells (pbmcs) from latently infected patients ex vivo. increased cellular drug uptake made the pnp-p more effective than panobinostat alone. therefore, this strategy demonstrates that nanotechnology can help improve the activation of latent hiv, and this study lays a foundation for further development of lra delivery systems for use against an hiv reservoir. |
WOS关键词 | HISTONE DEACETYLASE INHIBITOR ; CD4(+) T-CELLS ; HIV-1 LATENCY ; ANTIRETROVIRAL THERAPY ; REVERSING AGENTS ; INFECTED-CELLS ; REACTIVATION ; CHOLESTEROL ; RESERVOIRS ; ARGININE |
资助项目 | National Key R&D Program of China[2017YFSF110080] ; Program for the 13th Five-year Plan of China[2017ZX10202101004] ; National Science and Technology Major Project of China[2018ZX09J18111] ; Beijing key lab for HIV/AIDS research[BZ0089] |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
语种 | 英语 |
出版者 | AMER SCIENTIFIC PUBLISHERS |
WOS记录号 | WOS:000461761600010 |
资助机构 | National Key R&D Program of China ; Program for the 13th Five-year Plan of China ; National Science and Technology Major Project of China ; Beijing key lab for HIV/AIDS research |
URI标识 | http://www.irgrid.ac.cn/handle/1471x/2160513 |
专题 | 高能物理研究所 |
通讯作者 | Jiang, Xingwei; Ren, Suping; Yu, Qun |
作者单位 | 1.Beijing Inst Transfus Med, Beijing 100850, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Zhengzhou Univ, Sch Basic Med Sci, Zhengzhou 450001, Henan, Peoples R China 4.Capital Med Univ, Beijing Youan Hosp, Beijing Key Lab HIV AIDS Res, Beijing 100069, Peoples R China 5.Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100083, Peoples R China |
推荐引用方式 GB/T 7714 | Kuai, Qiyuan,Wang, Yu,Gao, Fenghua,et al. Peptide self-assembly nanoparticles loaded with panobinostat to activate latent human immunodeficiency virus[J]. Journal of biomedical nanotechnology,2019,15(5):979-992. |
APA | Kuai, Qiyuan.,Wang, Yu.,Gao, Fenghua.,Qi, Yingqiu.,Wang, Rui.,...&Yu, Qun.(2019).Peptide self-assembly nanoparticles loaded with panobinostat to activate latent human immunodeficiency virus.Journal of biomedical nanotechnology,15(5),979-992. |
MLA | Kuai, Qiyuan,et al."Peptide self-assembly nanoparticles loaded with panobinostat to activate latent human immunodeficiency virus".Journal of biomedical nanotechnology 15.5(2019):979-992. |
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来源:高能物理研究所
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