Bio-functional electrospun nanomaterials: from topology design to biological applications
文献类型:期刊论文
作者 | Han, Jinpeng1; Xiong, Likun1; Jiang, Xingyu2,3; Yuan, Xiaoyan4; Zhao, Yong5; Yang, Dayong1 |
刊名 | Progress in polymer science |
出版日期 | 2019-04-01 |
卷号 | 91页码:1-28 |
ISSN号 | 0079-6700 |
关键词 | Electrospinning Tissue Engineering Wound healing Drug delivery Diagnosis |
DOI | 10.1016/j.progpolymsci.2019.02.006 |
通讯作者 | Yuan, xiaoyan(yuanxy@tju.edu.cn) ; Zhao, yong(zhaoyong@buaa.edu.cn) ; Yang, dayong(dayong.yang@tju.edu.cn) |
英文摘要 | Electrospinning is a highly versatile technology to process polymers or related materials into fibrous materials with diameters ranging from micrometer to nanometer scale. in the early years, the electrospun materials were mainly polymers and the morphologies were mainly fibers. considerable progress has been achieved in the preceding two decades, which include electrospinning of metals, metal oxides, carbon species and organic/inorganic composites, and generating more morphologies beyond fibers such as beads, tubes and even hierarchical structures. in addition, a myriad of promising applications have been explored, mainly including biological, energy, catalysis, environment and mechanical enhancement, more than half focused on biological applications. electrospun nanomaterials can be designed to mimic the structural features of an extracellular matrix for cell growth and nutrients transport. such materials may be designed to enhance aesthetic wound healing, owing to the ability to absorb excess exudates, maintain a moist microenvironment to enhance epithelial regrowth, and offer painless to removal. electrospun nanomaterials encapsulated or with attached bioactive molecules and drugs are regarded as suitable candidates for delivery applications. they may also be utilized in medical diagnosis to enhance the specificity, sensitivity and signaling capabilities due to the high porosity and large surface area. in addition, electrospun nanomaterials can be assembled into a variety of fascinating biomimic structures and functions. all these attributes make electrospinning a powerful tool for fabricating bio-functional nanomaterials for a range of biological applications concerning human health that mainly include tissue engineering, wound healing, drug/bioactive molecules delivery, diagnosis, and biomimetics. this review highlights recent advances in the topological design and biological applications of electrospun bio-functional nanomaterials. the topologies are categorized to portray a comprehensive "topology periodic table", providing a concise and clear map offering a reference for scientists or engineers to opt for specific topology with desirable functions targeting a special application, as well as corresponding fabricadon strategy. the topologies of electrospun nanomaterials are classified into three categories: individuals, hybrids and assemblies according to the intrinsic logical relationships. the state-of-the-art progress on electrospun nanomaterials together with biological applications, challenges, and future directions are comprehensively summarized. (c) 2019 elsevier b.v. all rights reserved. |
WOS关键词 | SMOOTH-MUSCLE-CELLS ; MESENCHYMAL STEM-CELLS ; CARBON NANOTUBE YARNS ; POLYMER NANOFIBERS ; DRUG-DELIVERY ; EXTRACELLULAR-MATRIX ; BLOOD-VESSEL ; SUPERHYDROPHOBIC SURFACES ; COMPOSITE NANOFIBERS ; TISSUE REGENERATION |
资助项目 | National Natural Science Foundation of China[21575101] ; National Natural Science Foundation of China[21622404] ; National Natural Science Foundation of China[21621004] ; National Natural Science Foundation of China[51473118] |
WOS研究方向 | Polymer Science |
WOS类目 | Polymer Science |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000463126000001 |
资助机构 | National Natural Science Foundation of China |
URI标识 | http://www.irgrid.ac.cn/handle/1471x/2160783 |
专题 | 高能物理研究所 |
通讯作者 | Yuan, Xiaoyan; Zhao, Yong; Yang, Dayong |
作者单位 | 1.Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Key Lab Syst Bioengn, Sch Chem Engn & Technol,Minist Educ, Tianjin 300072, Peoples R China 2.Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 3.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Tianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct Mat, Tianjin 300072, Peoples R China 5.Beihang Univ, Sch Chem, Key Lab Bioinspired Smart Interfacial Sci & Techn, Minist Educ, Beijing 100191, Peoples R China |
推荐引用方式 GB/T 7714 | Han, Jinpeng,Xiong, Likun,Jiang, Xingyu,et al. Bio-functional electrospun nanomaterials: from topology design to biological applications[J]. Progress in polymer science,2019,91:1-28. |
APA | Han, Jinpeng,Xiong, Likun,Jiang, Xingyu,Yuan, Xiaoyan,Zhao, Yong,&Yang, Dayong.(2019).Bio-functional electrospun nanomaterials: from topology design to biological applications.Progress in polymer science,91,1-28. |
MLA | Han, Jinpeng,et al."Bio-functional electrospun nanomaterials: from topology design to biological applications".Progress in polymer science 91(2019):1-28. |
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来源:高能物理研究所
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