Au clusters treat rheumatoid arthritis with uniquely reversing cartilage/bone destruction
文献类型：期刊论文
| 作者 | Gao, Fuping1; Yuan, Qing1,2; Cai, Pengju1; Gao, Liang1,2; Zhao, Lina1; Liu, Meiqing1; Yao, Yawen1; Chai, Zhifang1,3; Gao, Xueyun1,2 |
| 刊名 | Advanced science
 |
| 出版日期 | 2019-04-03 |
| 卷号 | 6期号:7页码:13 |
| ISSN号 | 2198-3844 |
| 关键词 | Au clusters Bone destruction Inflammation Rheumatoid arthritis |
| DOI | 10.1002/advs.201801671 |
| 通讯作者 | Gao, xueyun(gaoxy@ihep.ac.cn) |
| 英文摘要 | Super-small nanoclusters may intrinsically trigger specific molecular pathway for disease treatment in vitro/vivo. to prove the hypothesis the super-small nanoclusters, e.g., au clusters, are directly used to treat rheumatoid arthritis (ra) in vitro/vivo. ra is a chronic autoimmune disease that is characterized by the inflammation of joints and the unreversible destruction of the cartilage/bone. au clusters significantly suppress lipopolysaccharide (lps)-induced proinflammatory mediator production in the murine macrophage cell line by inhibiting the signaling pathways that regulate the major proinflammatory mediator genes. in preclinical rat ra studies, au clusters strongly prevent type ii collagen-induced rat ra without systemic side effects. compared with the clinical first-line anchored anti-ra drug, methotrexate, au clusters equally inhibit inflammation in vivo. type ii collagen-induced rat ra is characterized with the destruction of cartilage/bone; treatment with au clusters reverses the destruction of cartilage/bone to its normal state. this is because au clusters directly inhibit receptor activator of nuclear factor-kappa b ligand (rankl)-induced osteoclast differentiation and function through the downregulation of osteoclast-specific genetic marker expression. however the methotrexate almost has no positive effect for this key issue in rat ra therapy. these data prove that the super-small nanoclusters, e.g., au clusters, could be a novel candidate nanodrug for ra treatment. |
| WOS关键词 | NF-KAPPA-B ; ACTIVATED PROTEIN-KINASE ; MODIFYING ANTIRHEUMATIC DRUGS ; INHIBITS OSTEOCLASTOGENESIS ; THERAPEUTIC STRATEGIES ; EXPRESSION ; RANKL ; GOLD ; PATHOGENESIS ; INDUCTION |
| 资助项目 | National Natural Science Foundation of China[21425522] ; National Natural Science Foundation of China[21727817] ; National Natural Science Foundation of China[31670976] ; National Natural Science Foundation of China[21390414] ; National Natural Science Foundation of China[81472851] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000463153100004 |
| 资助机构 | National Natural Science Foundation of China |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2161020 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gao, Xueyun |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Beijing Univ Technol, Dept Chem & Chem Engn, Beijing 100124, Peoples R China 3.Soochow Univ, State Key Lab Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Fuping,Yuan, Qing,Cai, Pengju,et al. Au clusters treat rheumatoid arthritis with uniquely reversing cartilage/bone destruction[J]. Advanced science,2019,6(7):13. |
| APA | Gao, Fuping.,Yuan, Qing.,Cai, Pengju.,Gao, Liang.,Zhao, Lina.,...&Gao, Xueyun.(2019).Au clusters treat rheumatoid arthritis with uniquely reversing cartilage/bone destruction.Advanced science,6(7),13. |
| MLA | Gao, Fuping,et al."Au clusters treat rheumatoid arthritis with uniquely reversing cartilage/bone destruction".Advanced science 6.7(2019):13. |
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来源：高能物理研究所
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