The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo
文献类型：期刊论文
| 作者 | Li,Juan1; Lei,Runhong1; Li,Xin2; Xiong,Fengxia1; Zhang,Quanyang2; Zhou,Yue2; Yang,Shengmei1; Chang,Yanan1; Chen,Kui1; Gu,Weihong1 |
| 刊名 | Particle and fibre toxicology
 |
| 出版日期 | 2018-01-17 |
| 卷号 | 15期号:1 |
| 关键词 | Fullerenols Gut microbiota Short-chain fatty acid (scfa) Blood lipids Butyrate-producing bacteria |
| ISSN号 | 1743-8977 |
| DOI | 10.1186/s12989-018-0241-9 |
| 通讯作者 | Wu,chongming(cmwu@implad.ac.cn) ; Xing,gengmei(xinggm@ihep.ac.cn) |
| 英文摘要 | Abstractbackgroundnanoparticles (nps) administered orally will meet the gut microbiota, but their impacts on microbiota homeostasis and the consequent physiological relevance remain largely unknown. here, we describe the modulatory effects and the consequent pharmacological outputs of two orally administered fullerenols nps (fol1 c60(oh)7(o)8 and fol113 c60(oh)11(o)6) on gut microbiota.resultsadministration of fol1 and fol113 nps for 4?weeks largely shifted the overall structure of gut microbiota in mice. the bacteria belonging to putative short-chain fatty acids (scfas)-producing genera were markedly increased by both nps, especially fol1. dynamic analysis showed that major scfas-producers and key butyrate-producing gene were significantly enriched after treatment for 7–28?days. the fecal contents of scfas were consequently increased, which was accompanied by significant decreases of triglycerides and total cholesterol levels in the blood and liver, with fol1 superior to fol113. under cultivation in vitro, fullerenols nps can be degraded by gut flora and exhibited a similar capacity of inulin to promote scfa-producing genera. the differential effects of fol1 and fol113 nps on the microbiome may be attributable to their subtly varied surface structures.conclusionsthe two fullerenol nps remarkably modulate the gut microbiota and selectively enrich scfa-producing bacteria, which may be an important reason for their anti-hyperlipidemic effect in mice. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S12989-018-0241-9 |
| 出版者 | BioMed Central |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2175670 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu,Chongming; Xing,Gengmei |
| 作者单位 | 1. 2.Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College |
| 推荐引用方式 GB/T 7714 | Li,Juan,Lei,Runhong,Li,Xin,et al. The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo[J]. Particle and fibre toxicology,2018,15(1). |
| APA | Li,Juan.,Lei,Runhong.,Li,Xin.,Xiong,Fengxia.,Zhang,Quanyang.,...&Xing,Gengmei.(2018).The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo.Particle and fibre toxicology,15(1). |
| MLA | Li,Juan,et al."The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo".Particle and fibre toxicology 15.1(2018). |
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来源：高能物理研究所
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