Increased oxidative dna damage, as assessed by urinary 8-hydroxy-2 '-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury
文献类型：期刊论文
| 作者 | Chen, CY; Qu, LY; Li, B; Xing, L; Jia, G; Wang, TC; Gao, YX; Zhang, PQ; Li, M; Chen, W |
| 刊名 | Clinical chemistry
 |
| 出版日期 | 2005-04-01 |
| 卷号 | 51期号:4页码:759-767 |
| ISSN号 | 0009-9147 |
| DOI | 10.1373/clinchem.2004.042093 |
| 通讯作者 | Chai, zf() |
| 英文摘要 | Background: mercury is a ubiquitous and highly toxic environmental pollutant. in this study, we evaluated the relationship between mercury exposure and oxidative stress, serum and urinary mercury concentrations, oxidative dna damage, and serum redox status in chronically mercury-exposed persons compared with healthy controls. methods: we measured urinary 8-hydroxy-2'-deoxyguanosine (8-ohdg), which we used as a biomarker of oxidative dna damage in the mercury-exposed persons, by hplc with electrochemical detection (ecd). we evaluated antioxidant status by measuring the activities of superoxide dismutase and glutathione peroxidase and the concentrations of total reduced glutathione and protein-bound thiols in serum. results: the significant increase in 8-ohdg concentrations in urine indicated that mercury-induced oxidative damage to dna occurred in vivo. differences in body mercury burden and antioxidant enzyme activities were statistically significant between the mercury-exposed persons and controls. serum and urinary mercury concentrations in the mercury-exposed persons were more than 40-fold higher than in controls. conclusions: mercury exposure can induce oxidative dna damage, whereas the antioxidative repair systems can be expected to minimize dna lesions caused by mercury. measurement of urinary 8-ohdg could be useful for evaluating in vivo oxidative dna damage in mercury-exposed populations. (c) 2005 american association for clinical chemistry. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; ELECTROCHEMICAL DETECTION ; GLUTATHIONE-PEROXIDASE ; HUMAN BLOOD ; METHYLMERCURY ; WORKERS ; 8-HYDROXYDEOXYGUANOSINE ; GENOTOXICITY ; CHLORIDE ; SELENIUM |
| WOS研究方向 | Medical Laboratory Technology |
| WOS类目 | Medical Laboratory Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000227936600011 |
| 出版者 | AMER ASSOC CLINICAL CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2175797 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chai, ZF |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Lab Nanoscale Mat & Related Bioenvironm Sci, Beijing 100049, Peoples R China 3.Guizhou Res & Design Inst Environm Sci, Guiyang, Peoples R China 4.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100871, Peoples R China 5.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, CY,Qu, LY,Li, B,et al. Increased oxidative dna damage, as assessed by urinary 8-hydroxy-2 '-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury[J]. Clinical chemistry,2005,51(4):759-767. |
| APA | Chen, CY.,Qu, LY.,Li, B.,Xing, L.,Jia, G.,...&Chai, ZF.(2005).Increased oxidative dna damage, as assessed by urinary 8-hydroxy-2 '-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury.Clinical chemistry,51(4),759-767. |
| MLA | Chen, CY,et al."Increased oxidative dna damage, as assessed by urinary 8-hydroxy-2 '-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury".Clinical chemistry 51.4(2005):759-767. |
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