Acute toxicological effects of copper nanoparticles in vivo
文献类型：期刊论文
| 作者 | Chen, Z; Meng, HA; Xing, GM; Chen, CY; Zhao, YL; Jia, GA; Wang, TC; Yuan, H; Ye, C; Zhao, F |
| 刊名 | Toxicology letters
 |
| 出版日期 | 2006-05-25 |
| 卷号 | 163期号:2页码:109-120 |
| 关键词 | Nanotoxicity Ld(50) Target organs Copper nanoparticles In vivo |
| ISSN号 | 0378-4274 |
| DOI | 10.1016/j.toxlet.2005.10.003 |
| 通讯作者 | Zhao, yl(zhaoyuliang@mail.ihep.ac.cn) |
| 英文摘要 | To assess the toxicity of copper nanoparticles (23.5 nm) in vivo, ld(50), morphological changes, pathological examinations and blood biochemical indexes of experimental mice are studied comparatively with micro-copper particles (17 mu m) and cupric ions (cucl(2)center dot 2h(2)o). the ld(50) for the nano-, micro-copper particles and cupric ions exposed to mice via oral gavage are 413, > 5000 and 110 mg/kg body weight, respectively. the toxicity classes of nano and ionic copper particles both are class 3 (moderately toxic), and micro-copper is class 5 (practically non-toxic) of hodge and sterner scale. kidney, liver and spleen are found to be target organs of nano-copper particles. nanoparticles induce gravely toxicological effects and heavy injuries on kidney. liver and spleen of experimental mice, but micro-copper particles do not, on mass basis. results indicate a gender dependent feature of nanotoxicity. several factors such as huge specific surface area, ultrahigh reactivity, exceeding consumption of h(+), etc. that likely cause the grave nanotoxicity observed in vivo are discussed. (c) 2005 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | GASTROINTESTINAL MUCOSA ; TITANIUM-DIOXIDE ; TOXICITY ; TRANSLOCATION ; GLUTATHIONE ; PARTICLES ; DISEASE ; DIET |
| WOS研究方向 | Toxicology |
| WOS类目 | Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000236820200004 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2175832 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhao, YL |
| 作者单位 | 1.Chinese Acad Sci, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China 2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China 4.Peking Univ, Hosp 3, Sch Publ Hlth, Dept Clin Lab, Beijing 100083, Peoples R China 5.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Z,Meng, HA,Xing, GM,et al. Acute toxicological effects of copper nanoparticles in vivo[J]. Toxicology letters,2006,163(2):109-120. |
| APA | Chen, Z.,Meng, HA.,Xing, GM.,Chen, CY.,Zhao, YL.,...&Wan, LJ.(2006).Acute toxicological effects of copper nanoparticles in vivo.Toxicology letters,163(2),109-120. |
| MLA | Chen, Z,et al."Acute toxicological effects of copper nanoparticles in vivo".Toxicology letters 163.2(2006):109-120. |
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来源：高能物理研究所
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