Photosensitized damage to telomere overhang and telomerase rna by riboflavin
文献类型：期刊论文
| 作者 | Liu, Yuxia; Du, Fuqiang; Lin, Weizhen; Tu, Tiecheng; Li, Wenxin; Lin, Nianyun |
| 刊名 | Progress in natural science-materials international
 |
| 出版日期 | 2008-04-10 |
| 卷号 | 18期号:4页码:401-404 |
| 关键词 | Telomere Telomerase Riboflavin Esr spin elimination Excited triplet state |
| ISSN号 | 1002-0071 |
| DOI | 10.1016/j.pnsc.2007.12.003 |
| 通讯作者 | Lin, weizhen(linweizhen@sinap.ac.cn) |
| 英文摘要 | By esr spin elimination and photocleavage assay, the mechanisms of one-electron oxidation damage of oligonucleotides by excited triplet state of riboflavin (rb) have been elucidated. the results demonstrate that rb, an endogenous photosensitizer, is capable of cleaving single-stranded telomeric overhang and the template region of telomerase rna under uva irradiation, resulting in blocking of reverse transcription of telomeric dna which leads to the apoptosis of cancer cells ultimately. (c) 2007 national natural science foundation of china and chinese academy of sciences. published by elsevier limited and science in china press. all rights reserved. |
| WOS关键词 | ONE-ELECTRON OXIDATION ; B-FORM DNA ; AQUEOUS-SOLUTIONS ; GGG TRIPLETS ; RADICALS ; BASES ; EPR |
| WOS研究方向 | Materials Science ; Science & Technology - Other Topics |
| WOS类目 | Materials Science, Multidisciplinary ; Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000255287800005 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2175885 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Lin, Weizhen |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Nucl Anal Tech, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yuxia,Du, Fuqiang,Lin, Weizhen,et al. Photosensitized damage to telomere overhang and telomerase rna by riboflavin[J]. Progress in natural science-materials international,2008,18(4):401-404. |
| APA | Liu, Yuxia,Du, Fuqiang,Lin, Weizhen,Tu, Tiecheng,Li, Wenxin,&Lin, Nianyun.(2008).Photosensitized damage to telomere overhang and telomerase rna by riboflavin.Progress in natural science-materials international,18(4),401-404. |
| MLA | Liu, Yuxia,et al."Photosensitized damage to telomere overhang and telomerase rna by riboflavin".Progress in natural science-materials international 18.4(2008):401-404. |
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来源：高能物理研究所
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