Disrupted white matter integrity in heroin dependence: a controlled study utilizing diffusion tensor imaging
文献类型：期刊论文
| 作者 | Liu, Haihong1; Li, Lin2; Hao, Yihui1; Cao, Dong1; Xu, Lin3; Rohrbaugh, Robert4; Xue, Zhimin1; Hao, Wei1; Shan, Baoci; Liu, Zhening1 |
| 刊名 | American journal of drug and alcohol abuse
 |
| 出版日期 | 2008 |
| 卷号 | 34期号:5页码:562-575 |
| ISSN号 | 0095-2990 |
| 关键词 | Brain imaging Diffusion tensor imaging Fractional anisotropy Heroin White matter integrity |
| DOI | 10.1080/00952990802295238 |
| 通讯作者 | Liu, zhening(zning1@163.com) |
| 英文摘要 | Objectives: fractional anisotropy (fa) via diffusion tensor imaging (dti) can quantify the white matter integrity. exposure to addictive drugs, such as alcohol, cocaine, methamphetamine, marijuana, and nicotine has been shown to alter fa. white matter abnormalities have been shown, but it remains unclear whether the white matter fa is altered in heroin dependence. methods: utilizing dti, we investigated the fa difference between heroin-dependent and control subjects by a voxel-based strategy. the fa values of the identified regions were calculated from the fa image of each subject and were correlated with clinical features including months of heroin use, age, education, and dose of methadone. results: reduced fa among 16 heroin dependent subjects was located in the bilateral frontal sub-gyral regionsm, right precentral and left cingulate gyrus. fa in the right frontal sub-gyral was negatively correlated with duration of heroin use. conclusion: the disrupted white matter integrity in right frontal white matter may occur in continuous heroin abuse. |
| WOS关键词 | VOXEL-BASED MORPHOMETRY ; MICROSTRUCTURAL INTEGRITY ; CHRONIC-ALCOHOLISM ; CORPUS-CALLOSUM ; BRAIN ; LEUKOENCEPHALOPATHY ; INHALATION ; DRAGON ; SCHIZOPHRENIA ; ADDICTION |
| WOS研究方向 | Psychology ; Substance Abuse |
| WOS类目 | Psychology, Clinical ; Substance Abuse |
| 语种 | 英语 |
| 出版者 | INFORMA HEALTHCARE |
| WOS记录号 | WOS:000259603400006 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2175902 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, Zhening |
| 作者单位 | 1.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Hunan, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Grad Sch, Beijing, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kuming, Peoples R China 4.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA |
| 推荐引用方式 GB/T 7714 | Liu, Haihong,Li, Lin,Hao, Yihui,et al. Disrupted white matter integrity in heroin dependence: a controlled study utilizing diffusion tensor imaging[J]. American journal of drug and alcohol abuse,2008,34(5):562-575. |
| APA | Liu, Haihong.,Li, Lin.,Hao, Yihui.,Cao, Dong.,Xu, Lin.,...&Liu, Zhening.(2008).Disrupted white matter integrity in heroin dependence: a controlled study utilizing diffusion tensor imaging.American journal of drug and alcohol abuse,34(5),562-575. |
| MLA | Liu, Haihong,et al."Disrupted white matter integrity in heroin dependence: a controlled study utilizing diffusion tensor imaging".American journal of drug and alcohol abuse 34.5(2008):562-575. |
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来源：高能物理研究所
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