Small molecule-capped gold nanoparticles as potent antibacterial agents that target gram-negative bacteria
文献类型：期刊论文
| 作者 | Zhao, Yuyun; Tian, Yue; Cui, Yan; Liu, Wenwen; Ma, Wanshun; Jiang, Xingyu |
| 刊名 | Journal of the american chemical society
 |
| 出版日期 | 2010-09-08 |
| 卷号 | 132期号:35页码:12349-12356 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/ja1028843 |
| 通讯作者 | Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | This report illustrates a new strategy in designing antibacterial agents a series of commercially available compounds, amino-substituted pyrimidines (themselves completely inactive as antibiotics), when presented on gold nanoparticles (nps), show antibacterial activities against multidrug-resistant clinical isolates, without external sources of energy such as ir. these pyrimidine-capped gold nps exert their antibiotic actions via sequestration of magnesium or calcium ions to disrupt the bacterial cell membrane, resulting in leakage of cytoplasmic contents including nucleic acids from compromised cell membranes, and via interaction with dna and inhibition of protein synthesis by internalized nps. these amino-substituted pyrimidine-capped gold nps induce bacterial resistance more slowly compared with conventional, small-molecule antibiotics and appear harmless to human cells; these nps may hence be useful for clinical applications. |
| WOS关键词 | ESCHERICHIA-COLI ; PSEUDOMONAS-AERUGINOSA ; SILVER NANOPARTICLES ; OUTER-MEMBRANE ; PATHOGENIC BACTERIA ; MULTIVALENT LIGANDS ; MAMMALIAN-CELLS ; RESISTANCE ; SURFACES ; DNA |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000281460100045 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2175972 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Jiang, Xingyu |
| 作者单位 | Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yuyun,Tian, Yue,Cui, Yan,et al. Small molecule-capped gold nanoparticles as potent antibacterial agents that target gram-negative bacteria[J]. Journal of the american chemical society,2010,132(35):12349-12356. |
| APA | Zhao, Yuyun,Tian, Yue,Cui, Yan,Liu, Wenwen,Ma, Wanshun,&Jiang, Xingyu.(2010).Small molecule-capped gold nanoparticles as potent antibacterial agents that target gram-negative bacteria.Journal of the american chemical society,132(35),12349-12356. |
| MLA | Zhao, Yuyun,et al."Small molecule-capped gold nanoparticles as potent antibacterial agents that target gram-negative bacteria".Journal of the american chemical society 132.35(2010):12349-12356. |
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来源：高能物理研究所
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