Cytotoxicity of zinc oxide nanoparticles: importance of microenvironment
文献类型：期刊论文
| 作者 | Yang, Sheng-Tao1; Liu, Jia-Hui1; Wang, Jing1; Yuan, Yuan1; Cao, Aoneng2; Wang, Haifang1,2; Liu, Yuanfang1,2; Zhao, Yuliang3,4 |
| 刊名 | Journal of nanoscience and nanotechnology
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 10期号:12页码:8638-8645 |
| 关键词 | Zinc oxide Nanoparticles Cytotoxicity Solubility Microenvironment |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2010.2491 |
| 通讯作者 | Wang, haifang() |
| 英文摘要 | While zno particles are widely used in many fields, including personal care products, the high toxicity of zno nanoparticles has been reported and aroused great health concerns. in this study, the cytotoxicity of zno nanoparticles was evaluated and, in particular, the role of microenvironment in their toxicity was investigated. our results show that zno nanoparticles are highly toxic to nih/3t3 cells, inducing viability loss, membrane leakage and morphology changes. the microenviroment, here the co(2) atmosphere under cell culture condition, promoted the solubilization of zno nanoparticles. then the released zn from zno nanoparticles induces the cytotoxicity. the importance of microenvironment on the zno nanotoxicity is presented and the implications to future nanotoxicology studies are discussed. |
| WOS关键词 | ZNO NANOPARTICLES ; NANOSTRUCTURED MATERIALS ; TOXICOLOGICAL IMPACT ; COMPARATIVE TOXICITY ; PARTICLE SOLUBILITY ; QUANTUM DOTS ; BULK ZNO ; CELLS ; BACTERIA ; NANOTECHNOLOGY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000283621400104 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176011 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Haifang |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 4.Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Sheng-Tao,Liu, Jia-Hui,Wang, Jing,et al. Cytotoxicity of zinc oxide nanoparticles: importance of microenvironment[J]. Journal of nanoscience and nanotechnology,2010,10(12):8638-8645. |
| APA | Yang, Sheng-Tao.,Liu, Jia-Hui.,Wang, Jing.,Yuan, Yuan.,Cao, Aoneng.,...&Zhao, Yuliang.(2010).Cytotoxicity of zinc oxide nanoparticles: importance of microenvironment.Journal of nanoscience and nanotechnology,10(12),8638-8645. |
| MLA | Yang, Sheng-Tao,et al."Cytotoxicity of zinc oxide nanoparticles: importance of microenvironment".Journal of nanoscience and nanotechnology 10.12(2010):8638-8645. |
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来源：高能物理研究所
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