Quaternized chitosan (qcs) nanoparticles as a novel delivery system for ammonium glycyrrhizinate
文献类型：期刊论文
| 作者 | Wang, Tie Wei1,2,3; Xu, Qing1,2; Wu, Yan1,2; Zeng, Ai Jun3; Li, Mingjun4; Gao, Hongxia4 |
| 刊名 | Journal of nanoscience and nanotechnology
 |
| 出版日期 | 2010-11-01 |
| 卷号 | 10期号:11页码:7402-7405 |
| 关键词 | Quaternized chitosan Poly(aspartic acid) Nanoparticles Lonotropic gelation Ammonium glycyrrhizinate Delivery |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2010.2827 |
| 通讯作者 | Wu, yan() |
| 英文摘要 | The aim of this study was to generate a new type of nanoparticles made of quaternized chitosan (qcs) and poly(aspartic acid) via the ionotropic gelation technique and to evaluate their potential for the association and delivery of ammonium glycyrrhizinate (gla). the effects of the ph value of nanoparticles, qcs molecular weight (mw) and poly(aspartic acid) concentration on gla encapsulation were studied. suitably ph value of nanoparticles, moderate qcs mw, optimal concentration ratio of poly(aspartic acid) and qcs favored higher gla encapsulation efficiency. the release of gla from nanoparticles was ph-dependent. fast release occurred in 0.1 m phosphate buffer solution (pbs, ph = 7.4), while the release was slow in 0.1 m hci (ph = 1.2). the results showed that the new qcs/poly(aspartic acid) nanoparticles have a promising potential in gla delivery system. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000283621300094 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176023 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu, Yan |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.China Agr Univ, Beijing 100083, Peoples R China 4.Jiamusi Univ, Affiliated Hosp 1, Jiamusi 154002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Tie Wei,Xu, Qing,Wu, Yan,et al. Quaternized chitosan (qcs) nanoparticles as a novel delivery system for ammonium glycyrrhizinate[J]. Journal of nanoscience and nanotechnology,2010,10(11):7402-7405. |
| APA | Wang, Tie Wei,Xu, Qing,Wu, Yan,Zeng, Ai Jun,Li, Mingjun,&Gao, Hongxia.(2010).Quaternized chitosan (qcs) nanoparticles as a novel delivery system for ammonium glycyrrhizinate.Journal of nanoscience and nanotechnology,10(11),7402-7405. |
| MLA | Wang, Tie Wei,et al."Quaternized chitosan (qcs) nanoparticles as a novel delivery system for ammonium glycyrrhizinate".Journal of nanoscience and nanotechnology 10.11(2010):7402-7405. |
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来源：高能物理研究所
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