Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in parkinson's disease
文献类型：期刊论文
| 作者 | Shi, Zhen-Hua1,2; Nie, Guangjun3; Duan, Xiang-Lin1; Rouault, Tracey4; Wu, Wen-Shuang1; Ning, Bo3; Zhang, Nan1; Chang, Yan-Zhong1; Zhao, Bao-Lu2 |
| 刊名 | Antioxidants & redox signaling
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 13期号:6页码:783-796 |
| ISSN号 | 1523-0864 |
| DOI | 10.1089/ars.2009.3018 |
| 通讯作者 | Chang, yan-zhong(frankyzchang@yahoo.com.hk) |
| 英文摘要 | Neuronal iron homeostasis disruption and oxidative stress are closely related to the pathogenesis of parkinson's disease (pd). adult iron-regulatory protein 2 knockout (ireb2(-/-)) mice develop iron accumulation in white matter tracts and nuclei in different brain area and display severe neurodegeneration in purkinje cells of the cerebrum. mitochondrial ferritin (mtft), a newly discovered ferritin, specifically expresses in high energy-consuming cells, including neurons of brain and spinal cord. interestingly, the decreased expression of mtft in cerebrum, but not in striatum, matches the differential neurodegeneration pattern in these ireb2(-/-) mice. to explore its effect on neurodegeneration, the effects of mtft expression on 6-hydrodopamine (6-ohda)-induced neuronal damage was examined. the overexpression of mtft led to a cytosolic iron deficiency in the neuronal cells and significantly prevented the alteration of iron redistribution induced by 6-ohda. importantly, mtft strongly inhibited mitochondrial damage, decreased production of the reactive oxygen species and lipid peroxidation, and dramatically rescued apoptosis by regulating bcl-2, bax and caspase-3 pathways. in conclusion, this study demonstrates that mtft plays an important role in preventing neuronal damage in an 6-ohda-induced parkinsonian phenotype by maintaining iron homeostasis. regulation of mtft expression in neuronal cells may provide a new neuroprotective strategy for pd. antioxid. redox signal. 13, 783-796. |
| WOS关键词 | GREEN TEA POLYPHENOLS ; ENDOPLASMIC-RETICULUM STRESS ; NEUROBLASTOMA SH-SY5Y CELLS ; CENTRAL-NERVOUS-SYSTEM ; LABILE IRON POOL ; ROS-NO PATHWAY ; OXIDATIVE STRESS ; COMPLEX-I ; NEURODEGENERATIVE DISORDERS ; INDUCED NEUROTOXICITY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| 出版者 | MARY ANN LIEBERT, INC |
| WOS记录号 | WOS:000280119800006 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176027 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chang, Yan-Zhong |
| 作者单位 | 1.Hebei Normal Univ, Coll Life Sci, Lab Mol Iron Metab, Shijiazhuang 050016, Hebei, Peoples R China 2.Acad Sinica, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing, Peoples R China 4.NICHHD, Program Mol Med, NIH, Bethesda, MD 20892 USA |
| 推荐引用方式 GB/T 7714 | Shi, Zhen-Hua,Nie, Guangjun,Duan, Xiang-Lin,et al. Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in parkinson's disease[J]. Antioxidants & redox signaling,2010,13(6):783-796. |
| APA | Shi, Zhen-Hua.,Nie, Guangjun.,Duan, Xiang-Lin.,Rouault, Tracey.,Wu, Wen-Shuang.,...&Zhao, Bao-Lu.(2010).Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in parkinson's disease.Antioxidants & redox signaling,13(6),783-796. |
| MLA | Shi, Zhen-Hua,et al."Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in parkinson's disease".Antioxidants & redox signaling 13.6(2010):783-796. |
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