The suppression of prostate lncap cancer cells growth by selenium nanoparticles through akt/mdm2/ar controlled apoptosis
文献类型：期刊论文
| 作者 | Kong, Ling1; Yuan, Qing1,2; Zhu, Huarui1; Li, Ying3; Guo, Quanyi4; Wang, Qin2; Bi, Xiaolin1; Gao, Xueyun1 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 32期号:27页码:6515-6522 |
| 关键词 | Selenium nanoparticles Prostate cancer Apoptosis Androgen receptor |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2011.05.032 |
| 通讯作者 | Bi, xiaolin(bixl@ihep.ac.cn) |
| 英文摘要 | The trace element selenium is suggested having cancer prevention activity and used as food supplement. previous results had shown selenium nanoparticles are safer compared with other selenium compounds like selenomethionine, sodium selenite and monomethylated selenium, however, its anticancer activity and intrinsic mechanisms are still elusive. here, we prepared selenium nanoparticles and investigated its inherent anticancer mechanisms. we found selenium nanoparticles inhibit growth of prostate lncap cancer cells partially through caspases mediated apoptosis. selenium nanoparticles suppress transcriptional activity of androgen receptor via down-regulating its mrna and protein expression. moreover, selenium nanoparticles activate akt kinase by increasing its phosphorylation, promote akt-dependent androgen receptor phosphorylation and mdm2 regulated degradation through proteasome pathway. we suggest selenium nanoparticles suppress prostate cancer cells growth by disrupting androgen receptor, implicating a potential application in cancer treatment. (c) 2011 elsevier ltd. all rights reserved. |
| WOS关键词 | HUMAN ANDROGEN RECEPTOR ; RED ELEMENTAL SELENIUM ; NANO-SE ; TOXICITY ; AKT ; INHIBITION ; MICE ; RNA ; DEGRADATION ; PROTEASOMES |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000293429700017 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176034 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Bi, Xiaolin |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Lanzhou Univ, Sch Life Sci, Inst Canc Biol & Drug Screening, Lanzhou 730000, Peoples R China 3.Gen Hosp Peoples Liberat Army, Dept Oncol, Beijing 100853, Peoples R China 4.Gen Hosp Peoples Liberat Army, Orthopaed Res Inst, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, Ling,Yuan, Qing,Zhu, Huarui,et al. The suppression of prostate lncap cancer cells growth by selenium nanoparticles through akt/mdm2/ar controlled apoptosis[J]. Biomaterials,2011,32(27):6515-6522. |
| APA | Kong, Ling.,Yuan, Qing.,Zhu, Huarui.,Li, Ying.,Guo, Quanyi.,...&Gao, Xueyun.(2011).The suppression of prostate lncap cancer cells growth by selenium nanoparticles through akt/mdm2/ar controlled apoptosis.Biomaterials,32(27),6515-6522. |
| MLA | Kong, Ling,et al."The suppression of prostate lncap cancer cells growth by selenium nanoparticles through akt/mdm2/ar controlled apoptosis".Biomaterials 32.27(2011):6515-6522. |
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来源：高能物理研究所
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