In vivo bone regeneration with injectable chitosan/hydroxyapatite/collagen composites and mesenchymal stem cells
文献类型：期刊论文
| 作者 | Huang, Zhi1; Chen, Yan2; Feng, Qing-Ling1; Zhao, Wei3; Yu, Bo4; Tian, Jing4; Li, Song-Jian4; Lin, Bo-Miao5 |
| 刊名 | Frontiers of materials science
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 5期号:3页码:301-310 |
| 关键词 | Mineralized collagen fibrils In situ-forming Injectable Mesenchymal stem cells Tissue engineered bone |
| ISSN号 | 2095-025X |
| DOI | 10.1007/s11706-011-0142-4 |
| 通讯作者 | Feng, qing-ling(biomater@mail.tsinghua.edu.cn) |
| 英文摘要 | For reconstruction of irregular bone defects, injectable biomaterials are more appropriate than the preformed biomaterials. we herein develop a biomimetic in situ-forming composite consisting of chitosan (cs) and mineralized collagen fibrils (nhac), which has a complex hierarchical structure similar to natural bone. the cs/nhac composites with or without mesenchymal stem cells (mscs) are injected into cancellous bone defects at the distal end of rabbit femurs. defects are assessed by radiographic, histological diagnosis and raman microscopy until 12 weeks. the results show that mscs improve the biocompatibility of cs/nhac composites and enhance new bone formation in vivo at 12 weeks. it can be concluded that the injectable cs/nhac composites combined with mscs may be a novel method for reconstruction of irregular bone defects. |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000208935600005 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176062 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Feng, Qing-Ling |
| 作者单位 | 1.Tsinghua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China 2.Southern Med Univ, Zhujiang Hosp, Dept Ultrason Diag, Guangzhou 510282, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China 4.Southern Med Univ, Zhujiang Hosp, Dept Orthoped, Guangzhou 510282, Guangdong, Peoples R China 5.Southern Med Univ, Zhujiang Hosp, Dept Radiol, Guangzhou 510282, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Zhi,Chen, Yan,Feng, Qing-Ling,et al. In vivo bone regeneration with injectable chitosan/hydroxyapatite/collagen composites and mesenchymal stem cells[J]. Frontiers of materials science,2011,5(3):301-310. |
| APA | Huang, Zhi.,Chen, Yan.,Feng, Qing-Ling.,Zhao, Wei.,Yu, Bo.,...&Lin, Bo-Miao.(2011).In vivo bone regeneration with injectable chitosan/hydroxyapatite/collagen composites and mesenchymal stem cells.Frontiers of materials science,5(3),301-310. |
| MLA | Huang, Zhi,et al."In vivo bone regeneration with injectable chitosan/hydroxyapatite/collagen composites and mesenchymal stem cells".Frontiers of materials science 5.3(2011):301-310. |
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来源：高能物理研究所
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