Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy
文献类型：期刊论文
| 作者 | Wu, Yan1; Jiao, Fang1,2; Han, Siyuan1,3; Fan, Tengfei1; Liu, Ying1; Li, Wei2; Hu, Liming3; Zhao, Yuliang1,2; Chen, Chunying1,2 |
| 刊名 | Nanomedicine-nanotechnology biology and medicine
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 7期号:6页码:945-954 |
| 关键词 | Drug delivery Controlled drug release Hyperbranched copolymer Anti-tumor activity Biocompatibility |
| ISSN号 | 1549-9634 |
| DOI | 10.1016/j.nano.2011.04.010 |
| 通讯作者 | Chen, chunying(chenchy@nanoctr.cn) |
| 英文摘要 | Novel amphiphilic copolymer nanoparticles (hpae-co-pla-dppe) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (dppe) segments were designed and synthesized that provided high encapsulation efficiency. these nanoparticles (nps) were used to encapsulate an antitumor model drug, doxorubicin (dox). the resulting nps exhibited high encapsulation efficiency to dox under an appropriate condition. in vitro release experiments revealed that the release of dox from nps was faster at ph 4.5 than that at ph 7.4 or ph 6.0. confocal microscopy observation indicated that the dox-loaded nps can enter cells and localize in lysosomes that can be released quickly into the cytoplasm. the dox-loaded nps showed comparable anticancer efficacy with the free drug both in vivo and in vitro. these results demonstrate a feasible application of the hyperbranched copolymer, hpae-co-pla-dppe, as a promising nanocarrier for intracellular delivery of antitumor drugs. from the clinical editor: in this paper, the development of novel amphiphilic copolymer nanoparticles is discussed with the goal of establishing high encapsulation efficiency for chemotherapy drugs. (c) 2011 elsevier inc. all rights reserved. |
| WOS关键词 | BLOCK-COPOLYMER ; PLGA NANOPARTICLES ; POLYMERIC MICELLES ; DELIVERY ; RELEASE ; DESIGN ; CHOLESTEROL ; LIPOSOMES ; PH |
| WOS研究方向 | Science & Technology - Other Topics ; Research & Experimental Medicine |
| WOS类目 | Nanoscience & Nanotechnology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000297699900031 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176069 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Chunying |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R China 3.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yan,Jiao, Fang,Han, Siyuan,et al. Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy[J]. Nanomedicine-nanotechnology biology and medicine,2011,7(6):945-954. |
| APA | Wu, Yan.,Jiao, Fang.,Han, Siyuan.,Fan, Tengfei.,Liu, Ying.,...&Chen, Chunying.(2011).Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy.Nanomedicine-nanotechnology biology and medicine,7(6),945-954. |
| MLA | Wu, Yan,et al."Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy".Nanomedicine-nanotechnology biology and medicine 7.6(2011):945-954. |
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