The interaction of serum proteins with carbon nanotubes depend on the physicochemical properties of nanotubes
文献类型：期刊论文
| 作者 | Du, Jiangfeng1,2,3; Ge, Cuicui2,3; Lu, Ying2,3; Bai, Ru2,3; Li, Denghua2,3; Yang, Yanlian2,3; Liao, Lifu1; Chen, Chunying2,3 |
| 刊名 | Journal of nanoscience and nanotechnology
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 11期号:11页码:10102-10110 |
| 关键词 | Carbon nanotubes Fetal bovine serum Cnt-protein interaction Peg modification Gel electrophoresis Mass spectrometry Atomic force microscope |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2011.4976 |
| 通讯作者 | Liao, lifu() |
| 英文摘要 | With more and more potential applications of carbon nanotubes (cnts) in different fields, the risk of exposure to cnts is increasing. the interaction between cnts and protein in biological media can affect the way cells interact with, recognize and process the nanoparticles, and this has important implications for safety considerations. in this study, the interaction of single-walled and multiwall cnts with various serum proteins was investigated. the adsorption kinetics of protein to cnts was investigated and a semi-qualitative analysis was provided by sodium dodecyl sulfate polyacrylamide gel electrophoresis (sds-page). matrix assisted laser desorption ionization/time of flight mass spectrometry (maldi-tof ms) was used to identify the protein species binding to cnts and atomic force microscopy (afm) was used to vividly demonstrate the adsorption model of protein on cnts. all the experimental results showed that the adsorption capacity of cnts for protein was highly dependent on the type, arrangement model, size and surface modification of cnts. significant quantity of proteins in serum could be quickly adsorbed by cnts, mainly including albumin, prealbumin, transferrin, and immunoglobulin. noncovalent functionalization of cnts by polyethylene glycol (peg) could decrease the protein adsorption on cnts. these results provide crucial insights into human serum proteins binding to different kinds of cnts, which is important for understanding the safe application of carbon nanotubes. |
| WOS关键词 | QUANTITATIVE-ANALYSIS ; PULMONARY RESPONSES ; FERRIC-OXIDE ; NANOPARTICLES ; CELLS ; DNA ; NANOMATERIALS ; TOXICITY ; FUNCTIONALIZATION ; NANOBIOTECHNOLOGY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000298765800138 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176106 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liao, Lifu |
| 作者单位 | 1.Univ S China, Coll Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Jiangfeng,Ge, Cuicui,Lu, Ying,et al. The interaction of serum proteins with carbon nanotubes depend on the physicochemical properties of nanotubes[J]. Journal of nanoscience and nanotechnology,2011,11(11):10102-10110. |
| APA | Du, Jiangfeng.,Ge, Cuicui.,Lu, Ying.,Bai, Ru.,Li, Denghua.,...&Chen, Chunying.(2011).The interaction of serum proteins with carbon nanotubes depend on the physicochemical properties of nanotubes.Journal of nanoscience and nanotechnology,11(11),10102-10110. |
| MLA | Du, Jiangfeng,et al."The interaction of serum proteins with carbon nanotubes depend on the physicochemical properties of nanotubes".Journal of nanoscience and nanotechnology 11.11(2011):10102-10110. |
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