Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a caenorhabditis elegans model of alzheimer's disease
文献类型：期刊论文
| 作者 | Luo YunFeng1,2; Zhang Jie3; Liu NianQing4; Luo Yuan5; Zhao BaoLu1 |
| 刊名 | Science china-life sciences
 |
| 出版日期 | 2011-06-01 |
| 卷号 | 54期号:6页码:527-534 |
| 关键词 | Alzheimer's disease Beta-amyloid(1-42) Copper C. elegans Oxidative stress |
| ISSN号 | 1674-7305 |
| DOI | 10.1007/s11427-011-4180-z |
| 通讯作者 | Zhao baolu(zhaobl@sun5.ibp.ac.cn) |
| 英文摘要 | Beta-amyloid (a beta) and copper play important roles in the pathogenesis of alzheimer's disease (ad). however, the behavioral correlativity and molecular mechanisms of a beta and copper toxicity have been investigated less often. in the present study, we investigated the interaction and toxicity of a beta 1-42 and copper in the a beta 1-42 transgenic caenorhabditis elegans worm model cl2006. our data show that the paralysis behavior of cl2006 worms significantly deteriorated after exposure to 10(-3) mol l(-1) copper ions. however, the paralysis behavior was dramatically attenuated with exposure to 10(-4) mol l(-1) copper ions. the exogenous copper treatment also partially changed the homeostatic balance of zinc, manganese, and iron. our data suggest that the accumulation of reactive oxygen species (ros) was responsible for the paralysis induced by a beta and copper in cl2006. the ros generation induced by a beta and copper appear to be through sod-1, prdx-2, skn-1, hsp-60 and hsp-16.2 genes. |
| WOS关键词 | OXIDATIVE STRESS HYPOTHESIS ; C-ELEGANS ; NEURODEGENERATIVE DISEASES ; GENE-EXPRESSION ; LIFE-SPAN ; BETA ; PROTEOTOXICITY ; REDUCTION ; MECHANISM ; PLAQUES |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000292050500005 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176115 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhao BaoLu |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Rutgers State Univ, Dept Cell Biol, Piscataway, NJ 08854 USA 4.Chinese Acad Sci, Inst High Energy Phys, Synchrotron Radiat Lab, Beijing 100049, Peoples R China 5.Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA |
| 推荐引用方式 GB/T 7714 | Luo YunFeng,Zhang Jie,Liu NianQing,et al. Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a caenorhabditis elegans model of alzheimer's disease[J]. Science china-life sciences,2011,54(6):527-534. |
| APA | Luo YunFeng,Zhang Jie,Liu NianQing,Luo Yuan,&Zhao BaoLu.(2011).Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a caenorhabditis elegans model of alzheimer's disease.Science china-life sciences,54(6),527-534. |
| MLA | Luo YunFeng,et al."Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a caenorhabditis elegans model of alzheimer's disease".Science china-life sciences 54.6(2011):527-534. |
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