Elimination pathways of systemically delivered sirna
文献类型：期刊论文
| 作者 | Huang, Yuanyu1; Hong, Junmei1; Zheng, Shuquan2; Ding, Yi1; Guo, Shutao3,4; Zhang, Hongyan2; Zhang, Xiuqin1; Du, Quan1; Liang, Zicai1 |
| 刊名 | Molecular therapy
 |
| 出版日期 | 2011-02-01 |
| 卷号 | 19期号:2页码:381-385 |
| ISSN号 | 1525-0016 |
| DOI | 10.1038/mt.2010.266 |
| 通讯作者 | Du, quan(quan.du@pku.edu.cn) |
| 英文摘要 | The elimination process of systemically administered small interfering rna (sirna) was investigated by using sirna labeled with an infrared fluorescent dye. a novel sirna elimination pathway was identified. in this pathway, liver-enriched sirna is secreted into the gallbladder and then emptied into the intestine. blocking this pathway resulted in the absence of sirna fluorescence within the intestine, with greatly enhanced sirna accumulation in liver and gallbladder at the same time. furthermore, we demonstrated that delivery carriers play an essential role in sirna distribution and elimination, highlighting their importance in sirna therapeutics. |
| WOS关键词 | RNA INTERFERENCE ; BIODISTRIBUTION ; CELLS ; GENE |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000286923000023 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176129 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Du, Quan |
| 作者单位 | 1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China 2.Suzhou Ribo Life Sci Co Ltd, Jiangsu, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 4.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yuanyu,Hong, Junmei,Zheng, Shuquan,et al. Elimination pathways of systemically delivered sirna[J]. Molecular therapy,2011,19(2):381-385. |
| APA | Huang, Yuanyu.,Hong, Junmei.,Zheng, Shuquan.,Ding, Yi.,Guo, Shutao.,...&Liang, Zicai.(2011).Elimination pathways of systemically delivered sirna.Molecular therapy,19(2),381-385. |
| MLA | Huang, Yuanyu,et al."Elimination pathways of systemically delivered sirna".Molecular therapy 19.2(2011):381-385. |
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来源：高能物理研究所
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