Au@pt nanostructures as oxidase and peroxidase mimetics for use in immunoassays
文献类型：期刊论文
| 作者 | He, Weiwei2,4; Liu, Ying3; Yuan, Jinshan3; Yin, Jun-Jie1; Wu, Xiaochun2; Hu, Xiaona2; Zhang, Ke2; Liu, Jianbo2; Chen, Chunying3; Ji, Yinglu2 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2011-02-01 |
| 卷号 | 32期号:4页码:1139-1147 |
| 关键词 | Platinum Nanostructures Oxidase Peroxidase Catalase Immunoassays |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2010.09.040 |
| 通讯作者 | Yin, jun-jie(junjie.yin@fda.hhs.gov) |
| 英文摘要 | In this paper, we demonstrated that au nanorods coated with a shell composed of pt nanodots (au@pt nanostructures) exhibited intrinsic oxidase-like, peroxidase-like and catalase-like activity, catalyzing oxygen and hydrogen peroxide reduction and the dismutation decomposition of hydrogen peroxide to produce oxygen. based on these findings, we established an au@pt nanostructures based enzyme linked immunosorbent assay (elisa) for the detection of mouse interleukin 2 (il-2). in comparison with natural enzymes, au@pt nanostructures have advantages of low cost, easy preparation, better stability, and tunable catalytic activity (compared with hrp), which make them a promising enzyme mimetic candidate and may find potential applications in biocatalysis, bioassays, and nano-biomedicine such as reactive oxygen species (ros)-related fields (anti-aging and therapeutics for neurodegenerative diseases and cancers). (c) 2010 elsevier ltd. all rights reserved. |
| WOS关键词 | OXYGEN REDUCTION REACTION ; GOLD NANORODS ; HYDROGEN-PEROXIDE ; GLUCOSE DETECTION ; PLATINUM NANOPARTICLES ; CATALYTIC-ACTIVITY ; SUPEROXIDE ANION ; CONTRAST AGENTS ; MECHANISM ; GROWTH |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000285675200021 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176143 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yin, Jun-Jie |
| 作者单位 | 1.US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA 2.Natl Ctr Nanosci & Technol, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Xuchang Univ, Inst Surface Micro & Nano Mat, Xuchang 461000, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Weiwei,Liu, Ying,Yuan, Jinshan,et al. Au@pt nanostructures as oxidase and peroxidase mimetics for use in immunoassays[J]. Biomaterials,2011,32(4):1139-1147. |
| APA | He, Weiwei.,Liu, Ying.,Yuan, Jinshan.,Yin, Jun-Jie.,Wu, Xiaochun.,...&Guo, Yuting.(2011).Au@pt nanostructures as oxidase and peroxidase mimetics for use in immunoassays.Biomaterials,32(4),1139-1147. |
| MLA | He, Weiwei,et al."Au@pt nanostructures as oxidase and peroxidase mimetics for use in immunoassays".Biomaterials 32.4(2011):1139-1147. |
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来源：高能物理研究所
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