A method of generating image-derived input function in a quantitative f-18-fdg pet study based on the shape of the input function curve
文献类型：期刊论文
| 作者 | Zhou, Shan1,2; Chen, Kewei3,4,5,6; Reiman, Eric M.3,6; Li, De-min2; Shan, Baoci1 |
| 刊名 | Nuclear medicine communications
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 32期号:12页码:1121-1127 |
| 关键词 | F-18-fluoro-2-deoxyglucose Image-derived input function Positron emission tomography Regional cerebral metabolic rate of glucose |
| ISSN号 | 0143-3636 |
| DOI | 10.1097/mnm.0b013e32834abd1b |
| 通讯作者 | Shan, baoci(shanbc@ihep.ac.cn) |
| 英文摘要 | Purpose a method for defining image-derived input function (idif) has been introduced and evaluated for the quantification of the regional cerebral metabolic rate of glucose in positron emission tomography studies. materials and methods first, a cubic region of interest containing the carotid artery was defined. the useful voxels in this cubic region, whose time-activity curves (tacs) decrease as assessed by linear regression after the initial rapid rise (about 2 min after injection), were selected, and their tacs were averaged to obtain the raw tac of the idif. the idif was obtained from the raw tac after correcting for partial volume and spillover effects using two blood samples. data from 16 human subjects were used to test the proposed method. the patlak approach was used to calculate the net f-18-fluoro-2-deoxyglucose (fdg) clearance with plasma-derived input function and our generated idif. results the net fdg clearances calculated with the image-derived input function generated by our approach are consistent with those calculated with plasma-derived input function. the relative error percentages of the net fdg clearances calculated with the image-derived input function and the plasma derived input function are about 5%. conclusion this study proposed a method to obtain the input function from the dynamic positron emission tomography images. the method was accurate and convenient to use. nucl med commun 32: 1121-1127 (c) 2011 wolters kluwer health vertical bar lippincott williams & wilkins. nuclear medicine communications 2011, 32: 1121-1127 |
| WOS关键词 | POSITRON-EMISSION-TOMOGRAPHY ; CEREBRAL METABOLIC-RATE ; INDEPENDENT COMPONENT ANALYSIS ; BRAIN TRANSFER CONSTANTS ; TIME-ACTIVITY CURVE ; NONINVASIVE QUANTIFICATION ; FDG-PET ; GRAPHICAL EVALUATION ; GLUCOSE-UTILIZATION ; BLOOD-FLOW |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000297299300003 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176174 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Shan, Baoci |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China 2.Zhengzhou Univ, Phys Sci & Technol Coll, Zhengzhou, Peoples R China 3.Banner Alzheimers Inst, Banner Good Samaritan Positron Emiss Tomog Ctr, Phoenix, AZ USA 4.Arizona State Univ, Dept Math & Stat, Tempe, AZ USA 5.Univ Arizona, Dept Radiol, Tucson, AZ 85724 USA 6.Arizona Alzheimers Consortium, Phoenix, AZ USA |
| 推荐引用方式 GB/T 7714 | Zhou, Shan,Chen, Kewei,Reiman, Eric M.,et al. A method of generating image-derived input function in a quantitative f-18-fdg pet study based on the shape of the input function curve[J]. Nuclear medicine communications,2011,32(12):1121-1127. |
| APA | Zhou, Shan,Chen, Kewei,Reiman, Eric M.,Li, De-min,&Shan, Baoci.(2011).A method of generating image-derived input function in a quantitative f-18-fdg pet study based on the shape of the input function curve.Nuclear medicine communications,32(12),1121-1127. |
| MLA | Zhou, Shan,et al."A method of generating image-derived input function in a quantitative f-18-fdg pet study based on the shape of the input function curve".Nuclear medicine communications 32.12(2011):1121-1127. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。