Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier
文献类型：期刊论文
| 作者 | Guo, Shutao1,2; Huang, Yuanyu3; Wei, Tuo1; Zhang, Wendi2; Wang, Weiwei2; Lin, Daoshu2; Zhang, Xu1; Kumar, Anil1; Du, Quan3; Xing, Jinfeng2 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:3页码:879-889 |
| 关键词 | Poly(epsilon caprolactone) Gene therapy Degradable polymers Poly(2 (dimethylamino ethyl)methacrylate) Amphiphilic copolymers |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2010.09.052 |
| 通讯作者 | Liang, xing-jie() |
| 英文摘要 | A group of amphiphilic cationic polymers methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) (pecd) were synthesized by combining ring-opening polymerization (rop) and atom transfer radical polymerization (atrp) methods to form nanoparticles (nps) the structures of these amphiphilic cationic polymers were characterized by (1)h nmr measurement the pecd nps have hydrophobic cores covered with hydrophilic peg and cationic pdmaema chains these self-assembly nanoparticles were characterized by dynamic light scattering (dls) technique pecd nps can effectively condense dna to form compact complexes of the size 65-160 nm suitable for gene delivery the in vitro gene transfection studies of hela and hepg2 cells show that pecd nps have better transfection efficiency compared to polyethylenimine (pei) and lipofectamine 2000 at low dose (n/p = 5) the cytotoxicity result shows that pecd nps/dna complexes at the optimal n/p ratio for transfection have comparable toxicity with pei and lipofectamine these results indicate that pecd nps have a great potential to be used as efficient polymeric carriers for gene transfection (c) 2010 elsevier ltd all rights reserved |
| WOS关键词 | SIRNA DELIVERY ; POLY(BETA-AMINO ESTER)S ; MOLECULAR-WEIGHT ; BLOCK-COPOLYMER ; DNA DELIVERY ; CO-DELIVERY ; IN-VITRO ; TRANSFECTION ; CELLS ; NANOPARTICLES |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000285322600023 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176182 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liang, Xing-Jie |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China 3.Peking Univ, Inst Mol Med, Lab Nucle Acid Technol, Beijing 100871, Peoples R China 4.Howard Univ, Dept Radiol, Washington, DC 20060 USA |
| 推荐引用方式 GB/T 7714 | Guo, Shutao,Huang, Yuanyu,Wei, Tuo,et al. Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier[J]. Biomaterials,2011,32(3):879-889. |
| APA | Guo, Shutao.,Huang, Yuanyu.,Wei, Tuo.,Zhang, Wendi.,Wang, Weiwei.,...&Liang, Xing-Jie.(2011).Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier.Biomaterials,32(3),879-889. |
| MLA | Guo, Shutao,et al."Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier".Biomaterials 32.3(2011):879-889. |
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