Learning and memory alterations are associated with hippocampal n-acetylaspartate in a rat model of depression as measured by h-1-mrs
文献类型：期刊论文
| 作者 | Xi, Guangjun1,2; Hui, Jiaojie1,2; Zhang, Zhijun1,2; Liu, Shanshan1,2; Zhang, Xiangrong1,2; Teng, Gaojun3; Chan, Kevin C.4,5; Wu, Ed X.4,5; Nie, Binbin6; Shan, Baoci6 |
| 刊名 | Plos one
 |
| 出版日期 | 2011-12-14 |
| 卷号 | 6期号:12页码:9 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0028686 |
| 通讯作者 | Xi, guangjun() |
| 英文摘要 | It is generally accepted that cognitive processes, such as learning and memory, are affected in depression. the present study used a rat model of depression, chronic unpredictable mild stress (cums), to determine whether hippocampal volume and neurochemical changes were involved in learning and memory alterations. a further aim was to determine whether these effects could be ameliorated by escitalopram treatment, as assessed with the non-invasive techniques of structural magnetic resonance imaging (mri) and magnetic resonance spectroscopy (mrs). our results demonstrated that cums had a dramatic influence on spatial cognitive performance in the morris water maze task, and cums reduced the concentration of neuronal marker n-acetylaspartate (naa) in the hippocampus. these effects could be significantly reversed by repeated administration of escitalopram. however, neither chronic stress nor escitalopram treatment influenced hippocampal volume. of note, the learning and memory alterations of the rats were associated with right hippocampal naa concentration. our results indicate that in depression, naa may be a more sensitive measure of cognitive function than hippocampal volume. |
| WOS关键词 | CHRONIC MILD STRESS ; MAGNETIC-RESONANCE-SPECTROSCOPY ; CHRONIC UNPREDICTABLE STRESS ; LONG-TERM POTENTIATION ; DECLARATIVE MEMORY ; MAJOR DEPRESSION ; ANTIDEPRESSANT TREATMENT ; RECEPTOR ACTIVATION ; CELL-PROLIFERATION ; MR SPECTROSCOPY |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| WOS记录号 | WOS:000298369100078 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176198 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Xi, Guangjun |
| 作者单位 | 1.Affiliated ZhongDa Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China 2.Southeast Univ, Inst Neuropsychiat, Nanjing, Jiangsu, Peoples R China 3.Southeast Univ, Inst Mol Imaging, Nanjing, Jiangsu, Peoples R China 4.Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Pokfulam, Hong Kong, Peoples R China 5.Univ Hong Kong, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China 6.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing, Peoples R China 7.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China 8.Sheffield Hallam Univ, Biomed Res Ctr, Sheffield S1 1WB, S Yorkshire, England |
| 推荐引用方式 GB/T 7714 | Xi, Guangjun,Hui, Jiaojie,Zhang, Zhijun,et al. Learning and memory alterations are associated with hippocampal n-acetylaspartate in a rat model of depression as measured by h-1-mrs[J]. Plos one,2011,6(12):9. |
| APA | Xi, Guangjun.,Hui, Jiaojie.,Zhang, Zhijun.,Liu, Shanshan.,Zhang, Xiangrong.,...&Reynolds, Gavin P..(2011).Learning and memory alterations are associated with hippocampal n-acetylaspartate in a rat model of depression as measured by h-1-mrs.Plos one,6(12),9. |
| MLA | Xi, Guangjun,et al."Learning and memory alterations are associated with hippocampal n-acetylaspartate in a rat model of depression as measured by h-1-mrs".Plos one 6.12(2011):9. |
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