Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: a voxel-based morphometry study
文献类型：期刊论文
| 作者 | Peng, Jing1; Liu, Jiangtao1; Nie, Binbin2; Li, Yang3; Shan, Baoci2; Wang, Gang3; Li, Kuncheng1 |
| 刊名 | European journal of radiology
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 80期号:2页码:395-399 |
| 关键词 | Major depressive disorder Gray matter Cerebellum Voxel-based morphometry Magnetic resonance imaging |
| ISSN号 | 0720-048X |
| DOI | 10.1016/j.ejrad.2010.04.006 |
| 通讯作者 | Li, kuncheng(likuncheng1955@yahoo.com.cn) |
| 英文摘要 | Purpose: to investigate cerebral and cerebellar gray matter abnormalities in patients with first-episode major depressive disorder (mdd). materials and methods: we examined the structural difference in regional gray matter density (gmd) between 22 first-episode mdd patients and 30 age-, gender- and education-matched healthy controls by optimized voxel-based morphometry (vbm) based on magnetic resonance imaging. results: compared with healthy controls, mdd patients showed decreased gmd in the right medial and left lateral orbitofrontal cortex, right dorsolateral prefrontal cortex (dlpfc), bilateral temporal pole, right superior temporal gyrus, bilateral anterior insular cortex, left parahippocampal gyrus, and left cerebellum. in addition, in mdd patients, there was a negative correlation between gmd values of the right dlpfc and the score of the depression rating scale. conclusions: our findings provided additional support for the involvement of limbic-cortical circuits in the pathophysiology of mdd and preliminary evidence that a defect involving the cerebellum may also be implicated. (c) 2010 published by elsevier ireland ltd. |
| WOS关键词 | ORBITOFRONTAL CORTEX ; NEUROPSYCHIATRIC DISORDERS ; UNIPOLAR DEPRESSION ; BRAIN ; CIRCUITRY ; CONNECTIONS ; DYSFUNCTION ; NETWORKS ; STIMULI ; EMOTION |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000296360500070 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176199 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Kuncheng |
| 作者单位 | 1.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China 3.Capital Med Univ, Anding Hosp, Dept Psychiat, Beijing 100088, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Jing,Liu, Jiangtao,Nie, Binbin,et al. Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: a voxel-based morphometry study[J]. European journal of radiology,2011,80(2):395-399. |
| APA | Peng, Jing.,Liu, Jiangtao.,Nie, Binbin.,Li, Yang.,Shan, Baoci.,...&Li, Kuncheng.(2011).Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: a voxel-based morphometry study.European journal of radiology,80(2),395-399. |
| MLA | Peng, Jing,et al."Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: a voxel-based morphometry study".European journal of radiology 80.2(2011):395-399. |
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