Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis
文献类型：期刊论文
| 作者 | Meng, Jie1; Xing, Jianmin3; Wang, Yingze1; Lu, Juan1; Zhao, Yuliang1,2; Gao, Xueyun2; Wang, Paul C.4; Jia, Lee1; Liang, Xingjie1 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2011 |
| 卷号 | 3期号:11页码:4713-4719 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c1nr10898k |
| 通讯作者 | Liang, xingjie(liangxj@nanoctr.cn) |
| 英文摘要 | Multi-hydroxylated endohedral metallofullerenol [gd@c(82)(oh)(22)](n) nanoparticles possess the general physico-chemical characteristics of most nanoparticles. they also exhibit uniquely low toxicity and antineoplastic efficacy. in the current study, the molecular mechanisms and epigenetic characteristics of the antineoplastic action of these nanoparticles are explored. human breast cancer mcf-7 and human umbilical vein endothelial ecv304 cell lines were used. cell viability assay, cell hierarchical cluster analysis by cdna microarray, semi-quantitative reverse transcription-polymerase chain reaction and western blot analysis were conducted to investigate the changes in molecular and cellular signaling pathways caused by [gd@c(82)(oh)(22)](n). the results demonstrated the high antitumor activity and low cytotoxicity of [gd@c(82)(oh)(22)](n) nanoparticles both in vivo and in vitro. their possible anti-tumor mechanisms were also discussed. the present study may provide new insight into the mechanism of action of these nanoparticles. |
| WOS关键词 | CATHEPSIN-S ; ENDOTHELIAL-CELLS ; GROWTH ; CISPLATIN ; ANGIOGENESIS ; INHIBITION ; EXPRESSION ; APOPTOSIS ; TOXICITY ; MODEL |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000296659000033 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176207 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liang, Xingjie |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 3.Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing 100029, Peoples R China 4.Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA |
| 推荐引用方式 GB/T 7714 | Meng, Jie,Xing, Jianmin,Wang, Yingze,et al. Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis[J]. Nanoscale,2011,3(11):4713-4719. |
| APA | Meng, Jie.,Xing, Jianmin.,Wang, Yingze.,Lu, Juan.,Zhao, Yuliang.,...&Liang, Xingjie.(2011).Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis.Nanoscale,3(11),4713-4719. |
| MLA | Meng, Jie,et al."Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis".Nanoscale 3.11(2011):4713-4719. |
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