Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses
文献类型：期刊论文
| 作者 | Zhang, Zhuzhen; Zhang, Fan; An, Peng; Guo, Xin; Shen, Yuanyuan; Tao, Yunlong; Wu, Qian; Zhang, Yuchao; Yu, Yu; Ning, Bo2 |
| 刊名 | Blood
 |
| 出版日期 | 2011-08-18 |
| 卷号 | 118期号:7页码:1912-1922 |
| ISSN号 | 0006-4971 |
| DOI | 10.1182/blood-2011-01-330324 |
| 通讯作者 | Wang, fudi(wangfd@sibs.ac.cn) |
| 英文摘要 | Systemic iron requirements are met predominantly through the recycling of iron from senescent erythrocytes by macrophages, a process in which the iron exporter ferroportin (fpn1) is considered to be essential. yet the role of fpn1 in macrophage iron recycling and whether it influences innate immune responses are poorly understood in vivo. we inactivated fpn1 in macrophages by crossing fpn1-floxed animals with macrophage-targeted lysm-cre or f4/80-cre transgenic mice. macrophage fpn1 deletion mice were overtly normal; however, they displayed a mild anemia and iron accumulation in splenic, hepatic, and bone marrow macrophages when fed a standard diet. iron loading was exacerbated after the administration of iron dextran or phenylhydrazine. when fpn1(lysm/lysm) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages. because immune responses can be altered by modulating iron status, we also examined the expression of proinflammatory cytokines. we found that expression levels of tnf-alpha and il-6 were significantly enhanced in fpn1lysm/lysm macrophages lacking fpn1. these studies demonstrate that fpn1 plays important roles in macrophage iron release in vivo and in modulating innate immune responses. (blood. 2011;118(7):1912-1922) |
| WOS关键词 | KUPFFER CELLS ; METABOLISM ; HEPCIDIN ; PROTEIN ; MICE ; EXPORTER ; FERRITIN ; DISEASE ; HEMOCHROMATOSIS ; ERYTHROPOIESIS |
| WOS研究方向 | Hematology |
| WOS类目 | Hematology |
| 语种 | 英语 |
| 出版者 | AMER SOC HEMATOLOGY |
| WOS记录号 | WOS:000294011500031 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176228 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Fudi |
| 作者单位 | 1.Chinese Acad Sci, Mineral Mol Nutr Lab, Key Lab Nutr & Metab, Shanghai Inst Biol Sci,Inst Nutr Sci,Grad Sch, Shanghai 200031, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing, Peoples R China 3.Univ Florida, Dept Food Sci & Human Nutr, Gainesville, FL 32611 USA 4.Royal Brisbane Hosp, Iron Metab Lab, Queensland Inst Med Res, Brisbane, Qld 4029, Australia |
| 推荐引用方式 GB/T 7714 | Zhang, Zhuzhen,Zhang, Fan,An, Peng,et al. Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses[J]. Blood,2011,118(7):1912-1922. |
| APA | Zhang, Zhuzhen.,Zhang, Fan.,An, Peng.,Guo, Xin.,Shen, Yuanyuan.,...&Wang, Fudi.(2011).Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses.Blood,118(7),1912-1922. |
| MLA | Zhang, Zhuzhen,et al."Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses".Blood 118.7(2011):1912-1922. |
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来源：高能物理研究所
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