Reducing the cytotoxicity of zno nanoparticles by a pre-formed protein corona in a supplemented cell culture medium
文献类型：期刊论文
| 作者 | Yin, Hong1,2; Chen, Rui3; Casey, Philip S.1; Ke, Pu Chun2; Davis, Thomas P.2,4; Chen, Chunying3 |
| 刊名 | Rsc advances
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:90页码:73963-73973 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c5ra14870g |
| 通讯作者 | Yin, hong(hong.yin@csiro.au) |
| 英文摘要 | The safety of zinc oxide (zno) nanoparticles (nps) remains a critical concern considering that they are a common constituent in cosmetics and sunscreen formulation. in our study, the cytotoxicity of pristine zno nps in a human hepatocellular carcinoma (hepg2) cell line was found to be significantly reduced when the nps were pre-incubated in a supplemented cell culture medium for 24 h prior to actual cell exposure. these pre-coated particles developed a stable protein layer on their surfaces, which facilitated further protein adsorption during the cell culture process. the amount of proteins adsorbed on pre-coated nps was significantly larger and the affinity between the nps and proteins was stronger, which inhibited both ros generation and zno dissolution and resulted in lower cytotoxicity compared to pristine nps. our studies on the continued evolution of a hard protein corona on zno nps in a supplemented cell culture medium and its effects on cytotoxicity demonstrate an effective and convenient way to achieve safe biomedical and environmental applications of zno nps and may be extrapolated to other classes of engineered nanomaterials. |
| WOS关键词 | ZINC-OXIDE NANOPARTICLES ; OXIDATIVE STRESS ; SILICA NANOPARTICLES ; SURFACE MODIFICATION ; CARBON NANOTUBES ; REACTIVE OXYGEN ; TOXICITY ; DISSOLUTION ; NANOMATERIALS ; RESPONSES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000360860500075 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176396 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yin, Hong |
| 作者单位 | 1.CSIRO, Mfg Flagship, Melbourne, Vic 3169, Australia 2.Monash Univ, ARC Ctr Excellence Convergent Bionano Sci & Techn, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 4.Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England |
| 推荐引用方式 GB/T 7714 | Yin, Hong,Chen, Rui,Casey, Philip S.,et al. Reducing the cytotoxicity of zno nanoparticles by a pre-formed protein corona in a supplemented cell culture medium[J]. Rsc advances,2015,5(90):73963-73973. |
| APA | Yin, Hong,Chen, Rui,Casey, Philip S.,Ke, Pu Chun,Davis, Thomas P.,&Chen, Chunying.(2015).Reducing the cytotoxicity of zno nanoparticles by a pre-formed protein corona in a supplemented cell culture medium.Rsc advances,5(90),73963-73973. |
| MLA | Yin, Hong,et al."Reducing the cytotoxicity of zno nanoparticles by a pre-formed protein corona in a supplemented cell culture medium".Rsc advances 5.90(2015):73963-73973. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。