Nanodrug formed by coassembly of dual anticancer drugs to inhibit cancer cell drug resistance
文献类型：期刊论文
| 作者 | Zhao, Yuanyuan1; Chen, Fei1,2; Pan, Yuanming1; Li, Zhipeng1; Xue, Xiangdong1,2; Okeke, Chukwunweike Ikechukwu1,2; Wang, Yifeng1,2; Li, Chan1; Peng, Ling3; Wang, Paul C.4 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2015-09-02 |
| 卷号 | 7期号:34页码:19295-19305 |
| 关键词 | Assemble Carrier-free Pure nanodrug Drug resistance Insoluble drugs |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.5b05347 |
| 通讯作者 | Ma, xiaowei(maxw@nanoctr.cn) |
| 英文摘要 | Carrier-free pure nanodrugs (pnds) that are composed entirely of pharmaceutically active molecules are regarded as promising candidates to be the next generation of drug formulations and are mainly formulated from supramolecular self-assembly of drug molecules. it benefits from the efficient use of drug compounds with poor aqueous solubility and takes advantage of nanoscale drug delivery systems. here, a type of all-in-one nanoparticle consisting of multiple drugs with enhanced synergistic antiproliferation efficiency against drug-resistant cancer cells has been created. to nanoparticulate the anticancer drugs, 10-hydroxycamptothecin (hcpt) and doxorubicin (dox) were chosen as a typical model. the resulting hd nanopartides (hd nps) were formulated by a "green" and convenient self-assembling method, and the water-solubility of 10-hydroxycamptothecin (hcpt) was improved 50-fold after nanosizing by coassembly with dox. the formation process was studied by observing the morphological changes at various reaction times and molar ratios of dox to hcpt. molecular dynamics (md) simulations showed that dox molecules tend to assemble around hcpt molecules through intermolecular forces. with the advantage of nanosizing, hd nps could improve the intracellular drug retention of dox to as much as 2-fold in drug-resistant cancer cells (mcf-7r). as a dual-drug-loaded nanoformulation, hd nps effectively enhanced drug c-ytotoxicity to drug-resistant cancer cells. the combination of hcpt and dox exhibited a synergistic effect as the nanosized hd nps improved drug retention in drug-resistant cancer cells against p-gp efflux in mcf-7r cells. furthermore, colony forming assays were applied to evaluate long-term inhibition of cancer cell proliferation, and these assays confirmed the greatly improved c-ytotoxicity of hd nps in drug-resistant cells compared to free drugs. |
| WOS关键词 | PRIMARY SYSTEMIC CHEMOTHERAPY ; INFLAMMATORY BREAST-CANCER ; TOPOISOMERASE-II ; P-GLYCOPROTEIN ; MULTIDRUG-RESISTANCE ; COATED NANOPARTICLES ; TARGETED DELIVERY ; PURE NANODRUGS ; IN-VITRO ; 10-HYDROXYCAMPTOTHECIN |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000360868700050 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176401 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Ma, Xiaowei |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Aix Marseille Univ, CNRS UMR 7325, Dept Chim, Ctr Interdisciplinaire Nanosci Marseille, F-13288 Marseille, France 4.Howard Univ, Dept Radiol, Mol Imaging Lab, Washington, DC 20060 USA |
| 推荐引用方式 GB/T 7714 | Zhao, Yuanyuan,Chen, Fei,Pan, Yuanming,et al. Nanodrug formed by coassembly of dual anticancer drugs to inhibit cancer cell drug resistance[J]. Acs applied materials & interfaces,2015,7(34):19295-19305. |
| APA | Zhao, Yuanyuan.,Chen, Fei.,Pan, Yuanming.,Li, Zhipeng.,Xue, Xiangdong.,...&Liang, Xing-Jie.(2015).Nanodrug formed by coassembly of dual anticancer drugs to inhibit cancer cell drug resistance.Acs applied materials & interfaces,7(34),19295-19305. |
| MLA | Zhao, Yuanyuan,et al."Nanodrug formed by coassembly of dual anticancer drugs to inhibit cancer cell drug resistance".Acs applied materials & interfaces 7.34(2015):19295-19305. |
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