Ph-sensitive polymer assisted self-aggregation of bis(pyrene) in living cells in situ with turn-on fluorescence
文献类型：期刊论文
| 作者 | Duan, Zhongyu1; Gao, Yu-Juan1,2; Qiao, Zeng-Ying2; Qiao, Shenglin2; Wang, Yongmei1,2; Hou, Chunyuan1,2; Wang, Lei2; Wang, Hao2 |
| 刊名 | Nanotechnology
 |
| 出版日期 | 2015-09-04 |
| 卷号 | 26期号:35页码:11 |
| ISSN号 | 0957-4484 |
| 关键词 | Self-assembly Bis(pyrene) Fluorescence In situ Living cells |
| DOI | 10.1088/0957-4484/26/35/355703 |
| 通讯作者 | Duan, zhongyu(zyduan@hebut.edu.cn) |
| 英文摘要 | Supramolecular self-assemblies with various nanostructures in organic and aqueous solutions have been prepared with desired functions. however, in situ construction of self-assembled superstructures in physiological conditions to achieve expected biological functions remains a challenge. here, we report a supramolecular system to realize the in situ formation of nanoaggregates in living cells. the bis(pyrene) monomers were dispersed inside of hydrophobic domains of ph-sensitive polymeric micelles and delivered to the lysosomes of cells. in the acidic lysosomes, the bis(pyrene) monomers were released and self-aggregated with turn-on fluorescence. we envision this strategy for in situ construction of supramolecular nanostructures in living cells will pave the way for molecular diagnostics in the future. |
| WOS关键词 | BUILDING-BLOCKS ; ORGANIC NANOPARTICLES ; INDUCED EMISSION ; DRUG-RESISTANCE ; SMALL MOLECULES ; LIVE CELLS ; RELEASE ; AMPHIPHILES ; NANOSTRUCTURES ; RECOGNITION |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| 出版者 | IOP PUBLISHING LTD |
| WOS记录号 | WOS:000360947200015 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176404 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Duan, Zhongyu |
| 作者单位 | 1.Hebei Univ Technol, Sch Chem Engn & Technol, Tianjin 300130, Peoples R China 2.Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Zhongyu,Gao, Yu-Juan,Qiao, Zeng-Ying,et al. Ph-sensitive polymer assisted self-aggregation of bis(pyrene) in living cells in situ with turn-on fluorescence[J]. Nanotechnology,2015,26(35):11. |
| APA | Duan, Zhongyu.,Gao, Yu-Juan.,Qiao, Zeng-Ying.,Qiao, Shenglin.,Wang, Yongmei.,...&Wang, Hao.(2015).Ph-sensitive polymer assisted self-aggregation of bis(pyrene) in living cells in situ with turn-on fluorescence.Nanotechnology,26(35),11. |
| MLA | Duan, Zhongyu,et al."Ph-sensitive polymer assisted self-aggregation of bis(pyrene) in living cells in situ with turn-on fluorescence".Nanotechnology 26.35(2015):11. |
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来源：高能物理研究所
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