Microarray based screening of peptide nano probes for her2 positive tumor
文献类型：期刊论文
| 作者 | Wang, Zihua1; Wang, Weizhi1; Bu, Xiangli1; Wei, Zewen1; Geng, Lingling1; Wu, Yue2; Dong, Chengyan2; Li, Liqiang2; Zhang, Di1; Yang, Shu1 |
| 刊名 | Analytical chemistry
 |
| 出版日期 | 2015-08-18 |
| 卷号 | 87期号:16页码:8367-8372 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.5b01588 |
| 通讯作者 | Wang, weizhi(wangwz@nanoctr.cn) |
| 英文摘要 | Peptides are excellent biointerface molecules and diagnostic probes with many advantages such as good penetration, short turnover time, and low cost. we report here an efficient peptide screening strategy based on in situ single bead sequencing on a microarray. two novel peptides ylffvfer (h6) and klrlewnr (h10) specifically binding to the tumor biomarker human epidermal growth factor receptor 2 (her2) with ak(d) of 10(-8) m were obtained from a 10(5) library. conjugated to nanoparticles, both the h6 and h10 probes showed specific accumulation in her2-positive tumor tissues in xenografted mice by in vivo imaging. |
| WOS关键词 | METASTATIC BREAST-CANCER ; ONE-COMPOUND LIBRARIES ; COMBINATORIAL LIBRARIES ; EXTRACELLULAR DOMAIN ; TARGETING PEPTIDES ; QUANTUM DOTS ; FACTOR-ALPHA ; BEAD ; CELLS ; IDENTIFICATION |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000359892100049 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176409 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Weizhi |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Peking Univ, Sch Basic Med Sci, Dept Radiat Med, Med Isotopes Res Ctr, Beijing 100191, Peoples R China 3.Inst Syst Biol, Seattle, WA 98109 USA 4.Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Beijing 102206, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zihua,Wang, Weizhi,Bu, Xiangli,et al. Microarray based screening of peptide nano probes for her2 positive tumor[J]. Analytical chemistry,2015,87(16):8367-8372. |
| APA | Wang, Zihua.,Wang, Weizhi.,Bu, Xiangli.,Wei, Zewen.,Geng, Lingling.,...&Hu, Zhiyuan.(2015).Microarray based screening of peptide nano probes for her2 positive tumor.Analytical chemistry,87(16),8367-8372. |
| MLA | Wang, Zihua,et al."Microarray based screening of peptide nano probes for her2 positive tumor".Analytical chemistry 87.16(2015):8367-8372. |
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