Abraxane, the nanoparticle formulation of paclitaxel can induce drug resistance by up-regulation of p-gp
文献类型：期刊论文
| 作者 | Zhao, Minzhi1; Lei, Chunni1; Yang, Yadong2; Bu, Xiangli1; Ma, Huailei1; Gong, He1; Liu, Juan1; Fang, Xiangdong2; Hu, Zhiyuan1,3; Fang, Qiaojun1 |
| 刊名 | Plos one
 |
| 出版日期 | 2015-07-16 |
| 卷号 | 10期号:7页码:19 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0131429 |
| 通讯作者 | Fang, xiangdong(fangxd@big.ac.cn) |
| 英文摘要 | P-glycoprotein (p-gp) can actively pump paclitaxel (ptx) out of cells and induces drug resistance. abraxane, a nanoparticle (np) formulation of ptx, has multiple clinical advantages over the single molecule form. however, it is still unclear whether abraxane overcomes the common small molecule drug resistance problem mediated by p-gp. here we were able to establish an abraxane-resistant cell line from the lung adenocarcinoma cell line a549. we compared the transcriptome of a549/abr resistant cell line to that of its parental cell line using rna-seq technology. several pathways were found to be up or down regulated. specifically, the most significantly up-regulated gene was abcb1, which translates into p-glycoprotein. we verified the overexpression of p-glycoprotein and confirmed its function by reversing the drug resistance with p-gp inhibitor verapamil. the results suggest that efflux pathway plays an important role in the abraxane-resistant cell line we established. however, the relevance of this p-gp mediated abraxane resistance in tumors of lung cancer patients remains unknown. |
| WOS关键词 | ALBUMIN-BOUND PACLITAXEL ; RNA-SEQ ; MULTIDRUG-RESISTANCE ; CANCER-CELLS ; ANTICANCER DRUGS ; CREMOPHOR-FREE ; TUMOR-CELLS ; GLYCOPROTEIN ; GENE ; ADHESION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000358198200005 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176414 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Fang, Xiangdong |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing 100101, Peoples R China 3.Beijing Proteome Res Ctr, Beijing Inst Radiat Med, Beijing 102206, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Minzhi,Lei, Chunni,Yang, Yadong,et al. Abraxane, the nanoparticle formulation of paclitaxel can induce drug resistance by up-regulation of p-gp[J]. Plos one,2015,10(7):19. |
| APA | Zhao, Minzhi.,Lei, Chunni.,Yang, Yadong.,Bu, Xiangli.,Ma, Huailei.,...&Fang, Qiaojun.(2015).Abraxane, the nanoparticle formulation of paclitaxel can induce drug resistance by up-regulation of p-gp.Plos one,10(7),19. |
| MLA | Zhao, Minzhi,et al."Abraxane, the nanoparticle formulation of paclitaxel can induce drug resistance by up-regulation of p-gp".Plos one 10.7(2015):19. |
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来源：高能物理研究所
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