Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles
文献类型：期刊论文
| 作者 | Yi, Xuan1,2; Yang, Kai1,2; Liang, Chao3,4; Zhong, Xiaoyan1,2; Ning, Ping1,2; Song, Guosheng3,4; Wang, Dongliang5; Ge, Cuicui1,2; Chen, Chunying5; Chai, Zhifang1,2 |
| 刊名 | Advanced functional materials
 |
| 出版日期 | 2015-08-05 |
| 卷号 | 25期号:29页码:4689-4699 |
| 关键词 | Cancer metastasis Copper sulfide Multimodal imaging Photothermal therapy Radiotherapy |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201502003 |
| 通讯作者 | Yi, xuan() |
| 英文摘要 | Combining different therapeutic strategies to treat cancer by overcoming limitations of conventional cancer therapies has shown great promise in both fundamental and clinical studies. herein, by adding i-131 when making iodine-doped cus nanoparticles, cus/[i-131]i nanoparticles are obtained, which after functionalization with polyethylene glycol (peg) are used for radiotherapy (rt) and photothermal therapy (ptt), by utilizing their intrinsic high near-infrared absorbance and the doped i-131-radioactivity, respectively. the combined rt and ptt based on cus/[i-131]i-peg is then conducted, achieving remarkable synergistic therapeutic effects as demonstrated in the treatment of subcutaneous tumors. in the meanwhile, as revealed by bimodal nuclear imaging and computed tomography (ct) imaging, it is found that cus/[i-131]i-peg nanoparticles after being injected into primary solid tumors could migrate to and retain in their nearby sentinel lymph nodes. importantly, the combined rt and ptt applied on those lymph nodes to assist surgical resection of primary tumors results in remarkably inhibited cancer metastasis and greatly prolonged animal survival. in vivo toxicology studies further reveal that our cus/i-peg is not obviously toxic to animals at fourfold of the treatment dose. this work thus demonstrates the potential of combining rt and ptt using a single nanoagent for imaging-guided treatment of metastatic tumors. |
| WOS关键词 | WALLED CARBON NANOTUBES ; NANO-GRAPHENE OXIDE ; IN-VIVO ; CANCER-CELLS ; GOLD NANORODS ; BIOMEDICAL APPLICATIONS ; CONVERSION EFFICIENCY ; LYMPHATIC METASTASIS ; OPTICAL-PROPERTIES ; THERANOSTIC AGENT |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000359025700015 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176415 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yi, Xuan |
| 作者单位 | 1.Soochow Univ, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China 2.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China 3.Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China 4.Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China 5.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yi, Xuan,Yang, Kai,Liang, Chao,et al. Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles[J]. Advanced functional materials,2015,25(29):4689-4699. |
| APA | Yi, Xuan.,Yang, Kai.,Liang, Chao.,Zhong, Xiaoyan.,Ning, Ping.,...&Liu, Zhuang.(2015).Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles.Advanced functional materials,25(29),4689-4699. |
| MLA | Yi, Xuan,et al."Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles".Advanced functional materials 25.29(2015):4689-4699. |
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