Formulation and evaluation of nanocrystalline cellulose as a potential disintegrant
文献类型：期刊论文
| 作者 | Wang, Chengyu3; Huang, Huijin3; Jia, Min3; Jin, Shanshan3; Zhao, Wenjing3; Cha, Ruitao1,2 |
| 刊名 | Carbohydrate polymers
 |
| 出版日期 | 2015-10-05 |
| 卷号 | 130页码:275-279 |
| 关键词 | Nanocrystalline cellulose Disintegrant Disintegration time |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2015.05.007 |
| 通讯作者 | Cha, ruitao(chart@nanoctr.cn) |
| 英文摘要 | Disintegrant is a typical excipient that improves the solubility, dissolution and bioavailability of drug. in this study, the application of nanocrystalline cellulose (ncc) as a potential disintegrant in the preparation of tablet was investigated. angle of repose of ncc was 44.26 degrees which was between l-hpc and mcc suggesting a good fluidity of ncc. swelling property of ncc was between cms-na and mcc indicating that ncc was of good absorbent ability. carbonate calcium tablet of which ncc was used as a disintegrant exhibited fastest disintegration time than known disintegrants. the disintegration and dissolution tests demonstrated that ncc showed effective disintegrant properties, e.g. consistently fast disintegration, rapid dissolution, and effectiveness at low concentrations. thus, we believe that ncc has a great potential as a disintegrant in tablets. (c) 2015 elsevier ltd. all rights reserved. |
| WOS关键词 | SUSTAINED-DRUG-RELEASE ; MICROFIBRILLATED CELLULOSE ; NANOFIBRILLAR CELLULOSE ; ACID-HYDROLYSIS ; PHARMACEUTICAL EXCIPIENT ; BARRIER PROPERTIES ; DOSAGE FORMS ; TABLETS ; DELIVERY ; STARCH |
| WOS研究方向 | Chemistry ; Polymer Science |
| WOS类目 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000357244900034 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176418 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Cha, Ruitao |
| 作者单位 | 1.Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Tianjin Univ Sci & Technol, Tianjin Key Lab Pulp & Paper, Tianjin 300457, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Chengyu,Huang, Huijin,Jia, Min,et al. Formulation and evaluation of nanocrystalline cellulose as a potential disintegrant[J]. Carbohydrate polymers,2015,130:275-279. |
| APA | Wang, Chengyu,Huang, Huijin,Jia, Min,Jin, Shanshan,Zhao, Wenjing,&Cha, Ruitao.(2015).Formulation and evaluation of nanocrystalline cellulose as a potential disintegrant.Carbohydrate polymers,130,275-279. |
| MLA | Wang, Chengyu,et al."Formulation and evaluation of nanocrystalline cellulose as a potential disintegrant".Carbohydrate polymers 130(2015):275-279. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。