Multistage vector delivery of sulindac and silymarin for prevention of colon cancer
文献类型：期刊论文
| 作者 | Scavo, Maria Principia1; Gentile, Emanuela1,2; Wolfram, Joy1,3; Gu, Jianhua1; Barone, Michele4; Evangelopoulos, Michael1; Martinez, Jonathan O.1; Liu, Xuewu1; Celia, Christian5; Tasciotti, Ennio1 |
| 刊名 | Colloids and surfaces b-biointerfaces
 |
| 出版日期 | 2015-12-01 |
| 卷号 | 136页码:694-703 |
| 关键词 | Colon cancer Drug delivery Fap Multistage vector Silymarin Sulindac |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2015.10.005 |
| 通讯作者 | Scavo, maria principia(mpsc227@uky.edu) |
| 英文摘要 | Familial adenomatous polyposis (fap) is an inherited condition secondary to germline mutations in the apc gene, thus resulting in the formation of hundreds of colonic adenomas that eventually progress into colon cancer. surgical removal of the colon remains the only treatment option to avoid malignancy, as long-term exposure to chemopreventive agents such as sulindac (a non-steroidal anti-inflammatory drug) and silymarin (phytoestrogen) is not feasible. here, we have developed a multistage silicon-based drug delivery platform for sulindac and silymarin that preferentially interacts with colon cancer cells as opposed to normal intestinal mucosa. preferential binding and internalization of these drugs into colon cancer cells was obtained using a targeting strategy against the protein meprin a, which we demonstrate is overexpressed in human colon cancer cells and in the small intestine of apc(min/+) mice. we propose that this delivery system could potentially be used to reduce drug-induced side effects in fap patients, thus enabling long-term prevention of adenoma formation. (c) 2015 elsevier b.v. all rights reserved. |
| WOS关键词 | FAMILIAL ADENOMATOUS POLYPOSIS ; BREAST-CANCER ; COLORECTAL-CANCER ; SILICON PARTICLES ; POLYMER MICELLES ; BONE-MARROW ; IN-VITRO ; CELLS ; THERAPEUTICS ; NANOVECTORS |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| WOS类目 | Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000367408100085 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176421 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Scavo, Maria Principia |
| 作者单位 | 1.Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA 2.Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA 3.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Univ Bari, Dept Emergency & Organ Transplantat, Gastroentrol Unit, I-70121 Bari, Italy 5.Univ G dAnnunzio Chieti, Dept Pharm, I-66013 Pescara, Italy 6.Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX 77030 USA 7.Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY 10065 USA |
| 推荐引用方式 GB/T 7714 | Scavo, Maria Principia,Gentile, Emanuela,Wolfram, Joy,et al. Multistage vector delivery of sulindac and silymarin for prevention of colon cancer[J]. Colloids and surfaces b-biointerfaces,2015,136:694-703. |
| APA | Scavo, Maria Principia.,Gentile, Emanuela.,Wolfram, Joy.,Gu, Jianhua.,Barone, Michele.,...&Shen, Haifa.(2015).Multistage vector delivery of sulindac and silymarin for prevention of colon cancer.Colloids and surfaces b-biointerfaces,136,694-703. |
| MLA | Scavo, Maria Principia,et al."Multistage vector delivery of sulindac and silymarin for prevention of colon cancer".Colloids and surfaces b-biointerfaces 136(2015):694-703. |
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