Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles
文献类型：期刊论文
| 作者 | Wang, Yan1,2; Zhu, Dan Dan2; Zhou, Jian1; Wang, Qi Lei2; Zhang, Can Yang3; Liu, Yue Jin1; Wu, Zhi Min1; Guo, Xin Dong2 |
| 刊名 | Colloids and surfaces b-biointerfaces
 |
| 出版日期 | 2015-12-01 |
| 卷号 | 136页码:536-544 |
| ISSN号 | 0927-7765 |
| 关键词 | Dissipative particle dynamics Micelle Drug delivery |
| DOI | 10.1016/j.colsurfb.2015.09.049 |
| 通讯作者 | Wu, zhi min(xdwuzm@xtu.edu.c) |
| 英文摘要 | In this work, the formation of polymeric micelles as drug delivery vehicles in an aqueous environment is investigated by dissipative particle dynamics (dpd) simulations. doxorubicin (dox) is selected as the model drug, whereas docosahexaenoic acid (dha) conjugated his10lys10 (dha-his(10)lys(10)) as the drug carrier. it is shown from dpd simulation that drug molecules and dha-his(10)lys(10) molecules could aggregate and form micelles under a defined composition recipe; drug molecules are homogeneously distributed inside the carrier matrix, on whose surface the stabilizer lysine segments are absorbed. under different compositions of drug and water, aggregate morphologies of polymeric micelles are observed as spherical, columnar, and lamellar structures. we finally proposed the formation mechanism of drug loaded polymeric micelles and apply it in practice by analyzing the simulated phenomena. all the results can effectively guide the experimental preparation of drug delivery system with desired properties or explore a novel polymeric micelle with high performance. (c) 2015 elsevier b.v. all rights reserved. |
| WOS关键词 | DISSIPATIVE PARTICLE DYNAMICS ; TRIBLOCK COPOLYMERS ; SELECTIVE SOLVENTS ; DIBLOCK COPOLYMERS ; MOLECULAR-DYNAMICS ; BLOCK-COPOLYMERS ; SURFACTANT ; DELIVERY ; BEHAVIOR ; NANOPARTICLES |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| WOS类目 | Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000367408100065 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176422 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu, Zhi Min |
| 作者单位 | 1.Xiangtan Univ, Sch Chem Engn, Xiangtan 411105, Peoples R China 2.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yan,Zhu, Dan Dan,Zhou, Jian,et al. Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles[J]. Colloids and surfaces b-biointerfaces,2015,136:536-544. |
| APA | Wang, Yan.,Zhu, Dan Dan.,Zhou, Jian.,Wang, Qi Lei.,Zhang, Can Yang.,...&Guo, Xin Dong.(2015).Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles.Colloids and surfaces b-biointerfaces,136,536-544. |
| MLA | Wang, Yan,et al."Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles".Colloids and surfaces b-biointerfaces 136(2015):536-544. |
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来源：高能物理研究所
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