Rna as a stable polymer to build controllable and defined nanostructures for material and biomedical applications
文献类型：期刊论文
| 作者 | Li, Hui1,2; Lee, Taek1,2,3; Dziubla, Thomas4; Pi, Fengmei1,2; Guo, Sijin1,2,5; Xu, Jing6; Li, Chan6; Haque, Farzin1,2; Liang, Xing-Jie6; Guo, Peixuan1,2 |
| 刊名 | Nano today
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 10期号:5页码:631-655 |
| 关键词 | Biopolymer Rna nanotechnology Rna nanostructure Rna therapeutics Phi29 dna packaging motor Prna |
| ISSN号 | 1748-0132 |
| DOI | 10.1016/j.nantod.2015.09.003 |
| 通讯作者 | Guo, peixuan(peixuan.guo@uky.edu) |
| 英文摘要 | The value of polymers is manifested in their vital use as building blocks in material and life sciences. ribonucleic acid (rna) is a polynucleic acid, but its polymeric nature in materials and technological applications is often overlooked due to an impression that rna is seemingly unstable. recent findings that certain modifications can make rna resistant to rnase degradation while retaining its authentic folding property and biological function, and the discovery of ultra-thermostable rna motifs have adequately addressed the concerns of rna unstability. rna can serve as a unique polymeric material to build varieties of nanostructures including nanoparticles, polygons, arrays, bundles, membrane, and microsponges that have potential applications in biomedical and material sciences. since 2005, more than a thousand publications on rna nanostructures have been published in diverse fields, indicating a remarkable increase of interest in the emerging field of rna nanotechnology. in this review, we aim to: delineate the physical and chemical properties of polymers that can be applied to rna; introduce the unique properties of rna as a polymer; review the current methods for the construction of rna nanostructures; describe its applications in material, biomedical and computer sciences; and, discuss the challenges and future prospects in this field. (c) 2015 the authors. published by elsevier ltd. |
| WOS关键词 | DNA-PACKAGING MOTOR ; PHI29 PRNA NANOPARTICLES ; WAY REVOLUTION MECHANISM ; VIABLE ESCHERICHIA-COLI ; DOUBLE-STRANDED-RNA ; CHEMICAL-MODIFICATION ; NUCLEIC-ACID ; MESSENGER-RNA ; DRUG-DELIVERY ; IN-VIVO |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000366883500010 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176424 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Guo, Peixuan |
| 作者单位 | 1.Univ Kentucky, Nanobiotechnol Ctr, Markey Canc Ctr, Lexington, KY 40536 USA 2.Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40536 USA 3.Sogang Univ, Dept Chem & Biomol Engn, Seoul, South Korea 4.Univ Kentucky, Dept Chem & Mat Engn, Lexington, KY 40506 USA 5.Univ Kentucky, Dept Chem, Lexington, KY 40506 USA 6.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Lab Nanomed & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hui,Lee, Taek,Dziubla, Thomas,et al. Rna as a stable polymer to build controllable and defined nanostructures for material and biomedical applications[J]. Nano today,2015,10(5):631-655. |
| APA | Li, Hui.,Lee, Taek.,Dziubla, Thomas.,Pi, Fengmei.,Guo, Sijin.,...&Guo, Peixuan.(2015).Rna as a stable polymer to build controllable and defined nanostructures for material and biomedical applications.Nano today,10(5),631-655. |
| MLA | Li, Hui,et al."Rna as a stable polymer to build controllable and defined nanostructures for material and biomedical applications".Nano today 10.5(2015):631-655. |
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