Surface charge-conversion polymeric nanoparticles for photodynamic treatment of urinary tract bacterial infections
文献类型：期刊论文
| 作者 | Liu, Shijie1,2; Qiao, Shenglin3; Li, Lili3; Qi, Guobin3; Lin, Yaoxin3; Qiao, Zengying3; Wang, Hao3; Shao, Chen1,2 |
| 刊名 | Nanotechnology
 |
| 出版日期 | 2015-12-11 |
| 卷号 | 26期号:49页码:12 |
| 关键词 | Supramolecular Bacteria Nanoparticles |
| ISSN号 | 0957-4484 |
| DOI | 10.1088/0957-4484/26/49/495602 |
| 通讯作者 | Liu, shijie() |
| 英文摘要 | Urinary tract infections are typical bacterial infections which result in a number of economic burdens. with increasing antibiotic resistance, it is urgent that new approaches are explored that can eliminate pathogenic bacteria without inducing drug resistance. antimicrobial photodynamic therapy (pdt) is a new promising tactic. it is a gentle in situ photochemical reaction in which a photosensitizer (ps) generates reactive oxygen species (ros) under laser irradiation. in this work, we have demonstrated chlorin e6 (ce6) encapsulated charge-conversion polymeric nanoparticles (nps) for efficiently targeting and killing pathogenic bacteria in a weakly acidic urinary tract infection environment. owing to the surface charge conversion of nps in an acidic environment, the nps exhibited enhanced recognition for gram-positive (ex. s. aureus) and gram-negative (ex. e. coli) bacteria due to the charge interaction. also, those nps showed significant antibacterial efficacy in vitro with low cytotoxicity. the mic value of nps to e. coli is 17.91 mu g ml(-1), compared with the free ce6 value of 29.85 mu g ml(-1). finally, a mouse acute cystitis model was used to assess the photodynamic therapy effects in urinary tract infections. a significant decline (p < 0.05) in bacterial cells between nps and free ce6 occurred in urine after photodynamic therapy treatment. and the plated counting results revealed a remarkable bacterial cells drop (p < 0.05) in the sacrificed bladder tissue. above all, this nanotechnology strategy opens a new door for the treatment of urinary tract infections with minimal side effects. |
| WOS关键词 | NEAR-INFRARED LIGHT ; MAGNETIC NANOPARTICLES ; ANTIBIOTIC DELIVERY ; IN-VITRO ; THERAPY ; CANCER ; RESISTANCE ; PHOTOSENSITIZERS ; AGENT ; FIGHT |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000366715200015 |
| 出版者 | IOP PUBLISHING LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176426 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, Shijie |
| 作者单位 | 1.FMMU, Xijing Hosp, Dept Urol, Xian, Peoples R China 2.FMMU, Xijing Hosp, State Key Lab Canc Biol, Xian, Peoples R China 3.Natl Ctr Nanosci & Technol NCNST, Lab Biol Effects Nanomat & Nanosafety, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shijie,Qiao, Shenglin,Li, Lili,et al. Surface charge-conversion polymeric nanoparticles for photodynamic treatment of urinary tract bacterial infections[J]. Nanotechnology,2015,26(49):12. |
| APA | Liu, Shijie.,Qiao, Shenglin.,Li, Lili.,Qi, Guobin.,Lin, Yaoxin.,...&Shao, Chen.(2015).Surface charge-conversion polymeric nanoparticles for photodynamic treatment of urinary tract bacterial infections.Nanotechnology,26(49),12. |
| MLA | Liu, Shijie,et al."Surface charge-conversion polymeric nanoparticles for photodynamic treatment of urinary tract bacterial infections".Nanotechnology 26.49(2015):12. |
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来源：高能物理研究所
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