One-step detection of pathogens and cancer biomarkers by the naked eye based on aggregation of immunomagnetic beads
文献类型：期刊论文
| 作者 | Chen, Yiping1,2; Xianyu, Yunlei1,2; Sun, Jiashu1,2; Niu, Yajing1,2; Wang, Yu3; Jiang, Xingyu1,2 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:2页码:1100-1107 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c5nr07044a |
| 通讯作者 | Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | This report shows that immunomagnetic beads (imbs) can act as the optical readout for assays, in addition to serving as the carrier for purification/separation. under the influence of an external magnet, imbs are attracted to coat one side of a test tube. imbs specifically bound to targets can form a narrow brown stripe, whereas free imbs will form a diffuse, yellow coating on the side of the test tube. target analytes can aggregate initially dispersed imbs in a sample concentration-dependent manner, yielding a color change from yellow to brown that can be seen with the naked eye. this assay combines the convenience of a lateral flow assay, allowing a one-step assay to finish within 15 min, with the sensitivity of an enzyme-linked immonosorbent assay. |
| WOS关键词 | GOLD NANOPARTICLES ; ULTRASENSITIVE DETECTION ; SMALL MOLECULES ; DNA ; IMMUNOASSAYS ; DISEASE ; TARGETS ; ASSAYS ; POINT |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000367258500048 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176429 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Capital Med Univ, Beijing Friendship Hosp, Beijing Inst Trop Med, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yiping,Xianyu, Yunlei,Sun, Jiashu,et al. One-step detection of pathogens and cancer biomarkers by the naked eye based on aggregation of immunomagnetic beads[J]. Nanoscale,2016,8(2):1100-1107. |
| APA | Chen, Yiping,Xianyu, Yunlei,Sun, Jiashu,Niu, Yajing,Wang, Yu,&Jiang, Xingyu.(2016).One-step detection of pathogens and cancer biomarkers by the naked eye based on aggregation of immunomagnetic beads.Nanoscale,8(2),1100-1107. |
| MLA | Chen, Yiping,et al."One-step detection of pathogens and cancer biomarkers by the naked eye based on aggregation of immunomagnetic beads".Nanoscale 8.2(2016):1100-1107. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。